Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.53 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| E-Methyl Cinnamate SCHEMBL901224 | 0.82 | CA12 (0.69) | GLATDP1MAPTHDAC3HDAC4 | |
| E-Methyl Cinnamate SCHEMBL27554805 | 0.82 | CA12 (0.69) | GLATDP1MAPTHDAC3HDAC4 | |
| E-Methyl Cinnamate SCHEMBL27554806 | 0.82 | CA12 (0.69) | GLATDP1MAPTHDAC3HDAC4 | |
| E-Methyl Cinnamate SCHEMBL112062 | 0.82 | CA12 (0.69) | GLATDP1MAPTHDAC3HDAC4 | |
| E-Methyl Cinnamate SCHEMBL101530 | 0.82 | CA12 (0.69) | GLATDP1MAPTHDAC3HDAC4 | |
| E-Methyl Cinnamate SCHEMBL2425288 | 0.82 | CA12 (0.69) | GLATDP1MAPTHDAC3HDAC4 | |
| E-Methyl Cinnamate SCHEMBL1862419 | 0.82 | CA12 (0.69) | GLATDP1MAPTHDAC3HDAC4 | |
| SCHEMBL28968012 | 0.82 | GLA (0.56) | GLATDP1MAPTHDAC3HDAC4 | |
| SCHEMBL29092879 | 0.82 | GLA (0.56) | GLATDP1MAPTHDAC3HDAC4 | |
| E-Methyl Cinnamate SCHEMBL11725144 | 0.81 | CA12 (0.67) | GLATDP1MAPTHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101360707-A | Thrombopoietin activity modulating compounds and methods | LIGAND PHARM INC (US) | 2009-02-04 | — | — | CN | claimed |
| EP-2268285-A1 | THERAPEUTIC COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009108507-A1 | THERAPEUTIC COMPOUNDS | MERCK & CO., INC. (US) | 2009-09-03 | — | — | WO | disclosed |
| CN-101360707-A | Thrombopoietin activity modulating compounds and methods | LIGAND PHARM INC (US) | 2009-02-04 | — | — | CN | disclosed |