Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390258 | 0.85 | GPR119 (0.63) | GPR119KCNH2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL1070910 | 0.80 | GPR119 (0.51) | GPR119KCNH2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL389501 | 0.79 | GPR119 (0.55) | GPR119KCNH2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL391191 | 0.79 | GPR119 (0.55) | GPR119KCNH2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL388126 | 0.77 | GPR119 (0.56) | GPR119KCNH2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL386303 | 0.75 | GPR119 (0.48) | GPR119KCNH2CYP3A4CYP2C19 | |
| SCHEMBL391166 | 0.74 | GPR119 (0.53) | GPR119KCNH2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL390011 | 0.74 | GPR119 (0.51) | GPR119KCNH2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL12904605 | 0.73 | GPR119 (0.48) | GPR119KCNH2CYP2C9 | |
| SCHEMBL389140 | 0.73 | GPR119 (0.49) | GPR119KCNH2CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-B1 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | ARENA PHARM INC (US) | 2011-01-12 | — | — | EP | disclosed |