Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.46 |
| ▸ | HPGD | P15428 | 8/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10708911 | 0.89 | KDM4E (0.55) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| SCHEMBL10706372 | 0.89 | HPGD (0.46) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL10668349 | 0.87 | KDM4E (0.58) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL10707395 | 0.86 | KDM4E (0.47) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL10708585 | 0.86 | KDM4E (0.43) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9636148 | 0.83 | KDM4E (0.53) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL10913381 | 0.83 | KDM4E (0.44) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL10914437 | 0.82 | HPGD (0.45) | KDM4EHPGDHSD17B10ALDH1A1PMP22 | |
| SCHEMBL9535838 | 0.81 | KDM4E (0.48) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| SCHEMBL6212721 | 0.81 | STAT3 (0.38) | KDM4EHPGDHSD17B10ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0155587-B1 | 1,7-DIAMINO-1,4-DIHYDRO-4-OXO-3(AZA)QUINOLINE-CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN TREATING BACTERIAL DISEASES | BAYER AG (DE) | 1988-06-08 | — | — | EP | disclosed |
| EP-0155587-A1 | 1,7-Diamino-1,4-dihydro-4-oxo-3(aza)quinoline-carboxylic acids, process for their preparation and their use in treating bacterial diseases | BAYER AG (DE) | 1985-09-25 | — | — | EP | disclosed |