Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10708911 | 0.92 | KDM4E (0.55) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL10699450 | 0.87 | KDM4E (0.42) | KDM4EALDH1A1HPGDHSD17B10ALB | |
| SCHEMBL2019858 | 0.87 | KDM4E (0.61) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL10709400 | 0.86 | TOP1 (0.45) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL10706372 | 0.83 | HPGD (0.46) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL12649231 | 0.82 | KDM4E (0.54) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL9534506 | 0.82 | STAT3 (0.35) | KDM4EALDH1A1HPGDPOLBTOP1 | |
| SCHEMBL10710610 | 0.81 | KDM4E (0.57) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL10709201 | 0.81 | KDM4E (0.46) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL10708585 | 0.81 | KDM4E (0.43) | KDM4EADRA2BMAPK1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259804-B1 | Pyrido[3,2,1-ij]-1,3,4-benzoxadiazine derivatives, process for their preparation, resulting pharmaceutical preparations and intermediates for use in the process | HOFFMANN LA ROCHE (CH) | 1993-11-18 | — | — | EP | disclosed |
| EP-0259804-A2 | Pyrido[3,2,1-ij]-1,3,4-benzoxadiazine derivatives, process for their preparation, resulting pharmaceutical preparations and intermediates for use in the process | F. HOFFMANN-LA ROCHE AG (CH) | 1988-03-16 | — | — | EP | disclosed |