Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CHRND | Q07001 | 6/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.40 |
| ▸ | CHRNG | P07510 | 2/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710843 | 0.88 | TSHR (0.46) | TSHRMAPK1 | |
| SCHEMBL15132246 | 0.81 | ESR1 (0.49) | ESR1TSHRESR2CNR1CNR2 | |
| SCHEMBL10660301 | 0.79 | CTSS (0.49) | ESR1TSHRESR2KMT2ANPSR1 | |
| SCHEMBL3055256 | 0.79 | TACR1 (0.50) | ESR1TSHRLMNACYP1A2CYP2D6 | |
| SCHEMBL3055258 | 0.79 | TACR1 (0.50) | ESR1TSHRLMNACYP1A2CYP2D6 | |
| SCHEMBL8246144 | 0.78 | BACE1 (0.53) | ESR1TSHRESR2KMT2ANPSR1 | |
| SCHEMBL973730 | 0.78 | BACE1 (0.53) | ESR1TSHRESR2KMT2ANPSR1 | |
| SCHEMBL24445702 | 0.77 | ESR1 (0.61) | ESR1TSHRCYP2C19ESR2KMT2A | |
| SCHEMBL5614087 | 0.77 | ESR1 (0.61) | ESR1TSHRCYP2C19ESR2KMT2A | |
| SCHEMBL5614085 | 0.77 | ESR1 (0.61) | ESR1TSHRCYP2C19ESR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0081838-B1 | CYCLOHEXYL AND PHENYL SUBSTITUTED ENKEPHALINS | G.D. Searle & Co. (US) | 1988-04-27 | — | — | EP | disclosed |