Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.63 |
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | DRD3 | P35462 | 4/20 | 0.62 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.62 |
| ▸ | PPARG | P37231 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11088265 | 0.96 | DRD4 (0.58) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL10714100 | 0.90 | DRD4 (0.59) | DRD4DRD2DRD3ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL10715208 | 0.89 | DRD4 (0.58) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL10957903 | 0.84 | DRD4 (0.55) | DRD4DRD2DRD3ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL10959588 | 0.83 | DRD4 (0.54) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL10715040 | 0.83 | KDM4E (0.58) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL4024256 | 0.81 | DRD4 (0.46) | DRD4DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL7907691 | 0.81 | MAOB (0.73) | KMT2AMAOBLMNA | |
| SCHEMBL11086087 | 0.81 | ALOX15 (0.58) | DRD4DRD2DRD3KDM4EGAA | |
| SCHEMBL11089177 | 0.81 | ALOX15 (0.55) | DRD4DRD2DRD3KMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4727067-A | TREATMENT OF ANGINA PECTORIS, CARDIAC ARRHYTHMIA, HYPERTENSION, DEPRESSION | CIBA-GEIGY CORPORATION (US) | 1988-02-23 | — | — | US | disclosed |
| US-4636511-A | ANTIARRHYTHMIC, HYPOTENSIVE | CIBA-GEIGY AG (US) | 1987-01-13 | — | — | US | disclosed |
| EP-0039892-B1 | SUBSTITUTED PHENYL ETHERS | CIBA-GEIGY AG (CH) | 1986-12-30 | — | — | EP | disclosed |
| US-4559354-A | ADRENERGIC BLOCKING AGENTS AND STIMULANTS; CARDIOTONIC, ANTIARRHYTHMIA AND INOTROPIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1985-12-17 | — | — | US | disclosed |
| US-4497813-A | ANTIARRHYTHMIA AGENTS, HYPOTENSIVE AGENTS, ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1985-02-05 | — | — | US | disclosed |
| EP-0015505-B1 | 3-AMINO-1,2-PROPANE DIOLS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE THEREOF | CIBA-GEIGY AG (CH) | 1984-08-08 | — | — | EP | disclosed |
| US-4460580-A | N-Alkylated aminoalcohols and their pharmaceutical compositions useful for the treatment of cardiac insufficiency | CIBA-GEIGY CORPORATION (US) | 1984-07-17 | — | — | US | disclosed |
| EP-0069838-A1 | Aralkylamino-ethoxy salicyl amides, and their pharmaceutical use | CIBA-GEIGY AG (CH) | 1983-01-19 | — | — | EP | disclosed |
| EP-0005848-B1 | N-ALKYLATED AMINOALCOHOLS AND THEIR SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CIBA-GEIGY AG (CH) | 1981-12-30 | — | — | EP | disclosed |
| EP-0039892-A1 | Substituted phenyl ethers | CIBA-GEIGY AG (CH) | 1981-11-18 | — | — | EP | disclosed |
| EP-0030030-A1 | Derivatives of 2-aminoethanol, processes for their preparation, pharmaceutical compositions containing such compounds and the use the latter | CIBA-GEIGY AG (CH) | 1981-06-10 | — | — | EP | disclosed |
| EP-0015505-A1 | 3-Amino-1,2-propane diols, process for their preparation, pharmaceutical compositions containing them and use thereof | CIBA-GEIGY AG (CH) | 1980-09-17 | — | — | EP | disclosed |
| EP-0005848-A1 | N-Alkylated aminoalcohols and their salts, process for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1979-12-12 | — | — | EP | disclosed |