Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 11/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10714905 | 0.85 | TDP2 (0.52) | TDP2AHRCMA1GRIA1CACNG8 | |
| SCHEMBL31117027 | 0.85 | TDP2 (0.52) | TDP2NTRK1METFGFR1KDR | |
| SCHEMBL10714430 | 0.81 | TDP2 (0.49) | TDP2CYP19A1CYP11B1CYP11B2CHEK1 | |
| SCHEMBL10713979 | 0.81 | TDP2 (0.49) | TDP2CYP19A1CYP11B1CYP11B2CHEK1 | |
| SCHEMBL10712665 | 0.77 | AHR (0.56) | TDP2CYP19A1CYP11B1CYP11B2CHEK1 | |
| SCHEMBL5373768 | 0.74 | TDP2 (0.49) | TDP2CYP19A1CYP11B1CYP11B2AHR | |
| SCHEMBL4297627 | 0.71 | TDP2 (0.46) | TDP2AHRCMA1PDK2GRIA1 | |
| SCHEMBL18189576 | 0.71 | AHR (0.53) | TDP2CYP11B1CYP11B2AHRCMA1 | |
| SCHEMBL5363780 | 0.71 | TDP2 (0.46) | TDP2AHRCMA1PDK2GRIA1 | |
| SCHEMBL10712589 | 0.71 | GRIA1 (0.52) | TDP2CYP19A1CYP11B1CYP11B2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670566-A | ANTIIFLAMMATORY AGENTS, ANTICOAGULANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-06-02 | — | — | US | disclosed |
| US-4440785-A | Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation | A. H. ROBINS COMPANY, INC. (US) | 1984-04-03 | — | — | US | disclosed |