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TDP2

Tyrosyl-DNA phosphodiesterase 2 · O95551 · TDP2 on Sugi Atlas →

46,713 patent compounds predicted against TDP2, 23,128 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL422023 SCHEMBL422023 1.00 16/20
SCHEMBL299769 SCHEMBL299769 0.52 9/20
SCHEMBL223361 SCHEMBL223361 0.44 9/20
2-Chloro-3-Morpholino-1,4-Naphthoquinone 2-Chloro-3-Morpholino-1,4-Naphthoquinone (SCHEMBL197256) 0.67 5/20
SCHEMBL398137 SCHEMBL398137 0.53 5/20
SCHEMBL208765 SCHEMBL208765 0.50 5/20
9,10-Phenanthrenequinone 9,10-Phenanthrenequinone (SCHEMBL43050) 1.00 4/20
SCHEMBL247037 SCHEMBL247037 0.79 4/20
SCHEMBL19954 SCHEMBL19954 0.67 4/20
SCHEMBL482129 SCHEMBL482129 0.55 4/20
SCHEMBL182798 SCHEMBL182798 0.54 4/20
SCHEMBL18844 SCHEMBL18844 0.52 4/20
SCHEMBL459201 SCHEMBL459201 0.51 4/20
SCHEMBL262246 SCHEMBL262246 0.51 4/20
SCHEMBL458428 SCHEMBL458428 0.49 4/20
SCHEMBL175567 SCHEMBL175567 0.48 4/20
SCHEMBL41861 SCHEMBL41861 0.46 4/20
SCHEMBL261018 SCHEMBL261018 0.46 4/20
SCHEMBL5997 SCHEMBL5997 0.43 4/20
SCHEMBL290258 SCHEMBL290258 0.41 4/20

Clinical trials — most relevant to TDP2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies PHASE1/PHASE2RECRUITING
Doxecitin and Doxribthymine in Adult Subjects With Thymidine Kinase 2 (TK2) Deficiency PHASE2RECRUITING
Safety Study of ABT-888 Plus Topotecan Hydrochloride to Treat Patients With Solid Tumors and Lymphomas PHASE1COMPLETED
A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors PHASE1COMPLETED
[18F]ACI-19626 PET in TDP-43 Proteinopathies EARLY_PHASE1RECRUITING
Exposure to Neurotoxins as Risk Factors for ALS nanCOMPLETED
Identification of New FTLD Genes nanUNKNOWN
Biomarker Research in Inherited Movement Disorders nanRECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
Parkinson's Research: The Organized Genetics Initiative nanCOMPLETED
Genetics of Neonatal Encephalopathy and Related Disorders nanRECRUITING
Genetics of Familial and Sporadic ALS nanCOMPLETED
Amyotrophic Lateral Sclerosis (ALS) Families Project nanRECRUITING
Genetics of Prostate Cancer in Young Patients nanCOMPLETED
Study of Markers of Cosmic Radiation Exposure and Effect Among Flight Crews nanCOMPLETED
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS nanRECRUITING
Long-read Genome Sequencing for the Molecular Diagnosis of Dystonia nanRECRUITING
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility nanRECRUITING
The Genetic and the Functional Study of DNA Repair System and the Susceptibility to Rheumatoid Arthritis nanCOMPLETED
Telomere Disclosure and Impact on Psychological Distress and Health Behaviors nanCOMPLETED
A National Retrospective Population Based Cohort Study of the Natural History of Ataxia Telangiectasia nanUNKNOWN
Genomic Translation for Amyotrophic Lateral Sclerosis Care nanCOMPLETED
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis nanUNKNOWN
Advancing Neurogenetic Diagnoses Through Long-Read Sequencing nanNOT_YET_RECRUITING
Epidemiological Study in FRONtoTemporal Dementia nanCOMPLETED
Gene Analysis of Parkinson's Disease nanCOMPLETED
Vascular Senescence and Atherosclerotic Plaque Vulnerability nanRECRUITING
Analysis of the Prognostic Role of Epigenetic Biomarkers in Relation to the Motor Decline in Parkinson's Disease nanUNKNOWN
Imaging Genetics of Laryngeal Dystonia nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a TDP2 binder may also engage these)

ProteinNameSimilarity
A7YWI9 — 1.000 A7YWI9 →
A5D8M0 — 1.000 A5D8M0 →
Q28FQ5 — 0.998 Q28FQ5 →
F1NW29 — 0.996 F1NW29 →
Q9JJX7 — 0.993 Q9JJX7 →
Q3T1H5 — 0.992 Q3T1H5 →
Q5XJA0 — 0.991 Q5XJA0 →
A8XU68 — 0.989 A8XU68 →
Q3TIU4 — 0.984 Q3TIU4 →
Q6AXQ5 — 0.983 Q6AXQ5 →
Q9XWG3 — 0.983 Q9XWG3 →
O45870 — 0.981 O45870 →
PDE12 2',5'-phosphodiesterase 12 0.981 landscape →
Q9VZS6 — 0.980 Q9VZS6 →
O74369 — 0.978 O74369 →
Q24239 — 0.978 Q24239 →
POLQ DNA polymerase theta 0.978 landscape →
INPP5B Type II inositol 1,4,5-trisphosphate 5-phosphatase 0.977 landscape →
Q5XHF8 — 0.977 Q5XHF8 →
Q8VIJ5 — 0.977 Q8VIJ5 →
O09053 — 0.976 O09053 →
Q8K337 — 0.976 Q8K337 →
P40015 — 0.976 P40015 →
F1QG30 — 0.976 F1QG30 →
Q94C95 — 0.976 Q94C95 →
Q80YE7 — 0.975 Q80YE7 →
Q80Y20 — 0.975 Q80Y20 →
Q91VF2 — 0.975 Q91VF2 →
Q08DF7 — 0.975 Q08DF7 →
DAPK1 Death-associated protein kinase 1 0.975 landscape →