Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KAT2B | Q92831 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30808005 | 0.97 | MAPT (0.54) | MAPTALDH1A1KAT2BLMNAKMT2A | |
| SCHEMBL112790 | 0.97 | MAPT (0.54) | MAPTALDH1A1KAT2BLMNAKMT2A | |
| SCHEMBL11056017 | 0.89 | KAT2B (0.60) | MAPTALDH1A1KAT2BLMNA | |
| SCHEMBL11056141 | 0.85 | MAPT (0.54) | MAPTALDH1A1KAT2BLMNAKMT2A | |
| SCHEMBL6151634 | 0.84 | MAPT (0.52) | MAPTALDH1A1KAT2BLMNAKMT2A | |
| SCHEMBL29391950 | 0.84 | MAPT (0.52) | MAPTALDH1A1KAT2BLMNAKMT2A | |
| SCHEMBL111935 | 0.84 | MAPT (0.52) | MAPTALDH1A1KAT2BLMNAKMT2A | |
| SCHEMBL2471755 | 0.82 | MAPT (0.50) | MAPTALDH1A1KAT2BLMNAKMT2A | |
| SCHEMBL11054352 | 0.82 | MAPT (0.49) | MAPTALDH1A1LMNAKMT2ATSHR | |
| SCHEMBL11059627 | 0.82 | MAPT (0.50) | MAPTALDH1A1KAT2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4637821-A | HAIR, DYEING | L'OREAL (FR) | 1987-01-20 | — | — | US | disclosed |
| US-4470826-A | HAIR DYES, NITRO DYES, DIRECT DYES | L'OREAL (FR) | 1984-09-11 | — | — | US | disclosed |