Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29161382 | 0.87 | MAPT (0.54) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL1827818 | 0.79 | MAPT (0.49) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL4515373 | 0.77 | ALDH1A1 (0.32) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL9215154 | 0.76 | ATM (0.40) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL14801972 | 0.76 | ATM (0.40) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL29905077 | 0.73 | MAPT (0.44) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL6184709 | 0.71 | MAPT (0.46) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL29191477 | 0.70 | MAPT (0.44) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL5855550 | 0.70 | MAPT (0.40) | MAPTKMT2AALDH1A1MEN1POLB | |
| SCHEMBL1137916 | 0.70 | MAPT (0.40) | MAPTKMT2AALDH1A1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226508-A1 | Indolo[3,2-c]quinoline derivatives, process for their preparation and their anti-tumour activity | SANOFI (FR) | 1987-06-24 | — | — | EP | disclosed |