Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 14/20 | 0.74 |
| ▸ | RARG | P13631 | 14/20 | 0.74 |
| ▸ | RARA | P10276 | 11/20 | 0.74 |
| ▸ | RXRA | P19793 | 13/20 | 0.62 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709119 | 0.86 | RARB (0.56) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL4709125 | 0.86 | RARB (0.56) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL156460 | 0.85 | RARB (1.00) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL10841477 | 0.85 | RARB (1.00) | RARBRARGRARARXRACYP26A1 | |
| Hydrochloric Acid SCHEMBL4432609 | 0.84 | RARB (0.97) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL4799160 | 0.83 | RARA (0.56) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL4799144 | 0.83 | RARA (0.56) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL7213492 | 0.83 | RARB (0.73) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL1073919 | 0.83 | RARB (0.73) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL14017920 | 0.82 | RARB (0.71) | RARBRARGRARARXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015059632-A1 | TREATMENT OF A NEURODEGENERATIVE DISEASE OR DISORDER | ACADIA PHARMACEUTICALS INC. (US) | 2015-04-30 | — | — | WO | disclosed |
| EP-2766018-A2 | RXR AGONISTS COMPOUNDS AND METHODS | Case Western Reserve University (US) | 2014-08-20 | — | — | EP | disclosed |
| WO-2013056232-A2 | RXR AGONISTS COMPOUNDS AND METHODS | CASE WESTERN RESERVE UNIVERSITY (US) | 2013-04-18 | — | — | WO | disclosed |
| EP-2451455-A2 | RXR AGONIST COMPOUNDS AND METHODS | Case Western Reserve University (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011006157-A2 | RXR AGONIST COMPOUNDS AND METHODS | CASE WESTERN RESERVE UNIVERSITY (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-1995011217-A1 | ISOTOPICALLY-LABELED RETINOIDS, THEIR PRODUCTION AND USE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1995-04-27 | — | — | WO | disclosed |