Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.70 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.52 |
| ▸ | SCD | O00767 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ensulizole SCHEMBL16277 | 0.93 | HDAC6 (0.79) | HDAC6NPBWR1SCDKDM4EALDH1A1 | |
| Ensulizole SCHEMBL29405567 | 0.93 | HDAC6 (0.79) | HDAC6NPBWR1SCDKDM4EALDH1A1 | |
| Ensulizole SCHEMBL4619449 | 0.93 | HDAC6 (0.79) | HDAC6NPBWR1SCDKDM4EALDH1A1 | |
| Ensulizole SCHEMBL2142368 | 0.92 | HDAC6 (0.77) | HDAC6NPBWR1SCDKDM4EALDH1A1 | |
| Ensulizole SCHEMBL1276069 | 0.92 | HDAC6 (0.77) | HDAC6NPBWR1SCDKDM4EALDH1A1 | |
| Ensulizole SCHEMBL17351653 | 0.92 | HDAC6 (0.77) | HDAC6NPBWR1SCDKDM4EALDH1A1 | |
| Ensulizole SCHEMBL3173650 | 0.92 | HDAC6 (0.77) | HDAC6NPBWR1SCDKDM4EALDH1A1 | |
| Ensulizole SCHEMBL22187023 | 0.91 | HDAC6 (0.75) | HDAC6NPBWR1SCDKDM4EALDH1A1 | |
| Ensulizole SCHEMBL27885503 | 0.91 | HDAC6 (0.75) | HDAC6NPBWR1SCDKDM4EALDH1A1 | |
| Ensulizole SCHEMBL1072605 | 0.90 | HDAC6 (0.87) | HDAC6NPBWR1SCDCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120184556-A1 | SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-07-19 | — | — | US | disclosed |
| EP-2456310-A1 | SUBSTITUTED BENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | Vanderbilt University (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011011722-A1 | SUBSTITUTED BENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | VANDERBILT UNIVERSITY (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184556-A1 | SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | GRM4, GRIK4, GRIA4 | HDAC6 608/4885NPBWR1 1636/4885SCD 2100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.