Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1072879 | 0.80 | REN (0.64) | RENKCNH2CYP3A4 | |
| SCHEMBL16966249 | 0.80 | REN (0.45) | RENKCNH2CYP3A4 | |
| SCHEMBL2795846 | 0.80 | KCNH2 (0.49) | RENKCNH2CYP3A4 | |
| SCHEMBL1074358 | 0.74 | REN (0.73) | RENKCNH2CYP3A4 | |
| SCHEMBL1072681 | 0.72 | REN (0.75) | RENKCNH2CYP3A4 | |
| SCHEMBL1518888 | 0.71 | REN (0.60) | RENKCNH2CYP3A4 | |
| SCHEMBL1518891 | 0.71 | REN (0.60) | RENKCNH2CYP3A4 | |
| SCHEMBL1073933 | 0.70 | REN (0.68) | RENKCNH2CYP3A4 | |
| SCHEMBL4453559 | 0.68 | KCNH2 (0.53) | RENKCNH2CYP3A4 | |
| SCHEMBL1228593 | 0.68 | REN (0.34) | RENKCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274295-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |