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SCHEMBL1072889

SCHEMBL1072889

CCOC(=O)CC(NC(=O)OCc1ccccc1)C1CCN(C(=O)OC(C)(C)C)CC1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 1/20 0.52
▸ P2RX7 Q99572 6/20 0.48
▸ HTT P42858 1/20 0.48
▸ YAP1 P46937 2/20 0.47
▸ STS P08842 1/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ PKM P14618 1/20 0.47
▸ SYK P43405 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ BACE1 P56817 1/20 0.47
▸ MAPT P10636 1/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ NTSR1 P30989 1/20 0.46
▸ NPSR1 Q6W5P4 1/20 0.46
▸ BCHE P06276 1/20 0.46
▸ ACHE P22303 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20660188 0.88 GPR119 (0.55) GPR119P2RX7HTTYAP1STS
SCHEMBL20660441 0.88 GPR119 (0.55) GPR119P2RX7HTTYAP1STS
SCHEMBL20660513 0.88 GPR119 (0.55) GPR119P2RX7HTTYAP1STS
SCHEMBL6505251 0.87 HTT (0.54) HTTL3MBTL1BCHEACHE
SCHEMBL12085391 0.86 GPR119 (0.52) GPR119P2RX7HTTYAP1STS
SCHEMBL25245210 0.84 GPR119 (0.59) GPR119P2RX7HTTYAP1STS
SCHEMBL17591749 0.84 GPR119 (0.59) GPR119P2RX7HTTYAP1STS
SCHEMBL3661565 0.84 GPR119 (0.57) GPR119P2RX7HTTYAP1STS
SCHEMBL21062628 0.83 GPR119 (0.56) GPR119P2RX7YAP1STSSYK
SCHEMBL22552460 0.83 GPR119 (0.56) GPR119P2RX7YAP1STSSYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9139581-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2015-09-22 — — US disclosed
US-9139581-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2015-09-22 — — US disclosed
US-20130029944-A1 INHIBITORS OF PROTEIN KINASES PORTOLA PHARMACEUTICALS, INC. (US) 2013-01-31 — — US disclosed
US-20130029944-A1 INHIBITORS OF PROTEIN KINASES PORTOLA PHARMACEUTICALS, INC. (US) 2013-01-31 — — US disclosed
US-8258144-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2012-09-04 — — US disclosed
US-8258144-B2 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2012-09-04 — — US disclosed
EP-2271631-A2 INHIBITORS OF PROTEIN KINASES Portola Pharmaceuticals, Inc. (US) 2011-01-12 — — EP disclosed
US-20090298823-A1 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2009-12-03 — — US disclosed
US-20090298823-A1 Inhibitors of protein kinases PORTOLA PHARMACEUTICALS, INC. (US) 2009-12-03 — — US disclosed
WO-2009131687-A2 INHIBITORS OF PROTEIN KINASES PORTOLA PHARMACEUTICALS, INC. (US) 2009-10-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130029944-A1 INHIBITORS OF PROTEIN KINASES SYK, BTK, JAK2 GPR119 2075/4885P2RX7 1530/4885HTT 2628/4885
US-20090298823-A1 Inhibitors of protein kinases SYK, BTK, JAK2 GPR119 2075/4885P2RX7 1530/4885HTT 2628/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.