Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.60 |
| ▸ | CMA1 | P23946 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PREP | P48147 | 2/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | KLK7 | P49862 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7533944 | 0.92 | ACE (0.65) | ACECMA1LMNAKLK5ACE2 | |
| SCHEMBL29131321 | 0.92 | ACE (0.65) | ACECMA1LMNAKLK5ACE2 | |
| SCHEMBL29131320 | 0.92 | ACE (0.65) | ACECMA1LMNAKLK5ACE2 | |
| SCHEMBL10736853 | 0.88 | ACE (0.61) | ACELMNAACE2 | |
| SCHEMBL10736067 | 0.87 | ACE (0.59) | ACECMA1LMNAPREPKLK5 | |
| SCHEMBL15459281 | 0.85 | ACE (0.53) | ACECMA1LMNAPREPACE2 | |
| SCHEMBL15459284 | 0.85 | ACE (0.53) | ACECMA1LMNAPREPACE2 | |
| SCHEMBL20052434 | 0.85 | ACE (0.53) | ACECMA1LMNAPREPACE2 | |
| SCHEMBL20349138 | 0.85 | CASP1 (0.57) | ACECMA1LMNAPREPACE2 | |
| SCHEMBL15459276 | 0.85 | CASP1 (0.57) | ACECMA1LMNAPREPACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4642315-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1987-02-10 | — | — | US | disclosed |
| US-4587234-A | HYPOTENSIVES | E. R. SQUIBB & SONS, INC. (US) | 1986-05-06 | — | — | US | disclosed |
| US-4499079-A | ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-02-12 | — | — | US | disclosed |