CASP1

Caspase-1 · P29466 · CASP1 on Sugi Atlas →

377,631 patent compounds predicted against CASP1, 223,293 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Esculin (SCHEMBL2893)	1.00	5/20
Esculin (SCHEMBL2894)	1.00	5/20
SCHEMBL6627	0.49	5/20
SCHEMBL37694	0.47	5/20
Reserpine (SCHEMBL2589)	1.00	4/20
Umbelliferone (SCHEMBL22018)	1.00	4/20
Esculetin (SCHEMBL24641)	1.00	4/20
SCHEMBL37677	1.00	4/20
Fisetin (SCHEMBL39454)	1.00	4/20
Reserpine (SCHEMBL28129)	0.84	4/20
Flavonol (SCHEMBL20246)	0.71	4/20
SCHEMBL21372	0.52	4/20
Topotecan (SCHEMBL3836)	1.00	3/20
Topotecan (SCHEMBL7247)	1.00	3/20
Topotecan (SCHEMBL7248)	1.00	3/20
Topotecan (SCHEMBL10278)	1.00	3/20
Quinacrine (SCHEMBL19225)	1.00	3/20
Quinacrine (SCHEMBL20205)	1.00	3/20
Homidium (SCHEMBL20520)	1.00	3/20
Homidium (SCHEMBL27609)	1.00	3/20

Clinical trials — most relevant to CASP1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?	PHASE4	COMPLETED
The Effect of Trimetazidine on the Clinical Outcome of Acute Ischemic Stroke Patients	PHASE3	COMPLETED
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19	PHASE2	COMPLETED
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery	PHASE1/PHASE2	UNKNOWN
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear	nan	UNKNOWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis	nan	COMPLETED
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients	nan	UNKNOWN
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients	nan	UNKNOWN
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Probiotics and Systemic Inflammation in Patients With Metabolic Syndrome and High Cardiovascular Risk	nan	WITHDRAWN
Caspase-1 Activity, IL-1beta, and IL-18 in Patients With FMF	nan	NOT_YET_RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Effect of Low Dose of Colchicine on Platelet Reactivity	nan	COMPLETED
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Role of Type 2 Diabetes in Potentiating the Inflammatory Response Post Extracorporeal Circulation After Cardiac Surgery	nan	WITHDRAWN
Pigeon Peas (Cajanus Cajan) : a Natural Anti-inflammatory Facilitating Weight Loss in Obese Patients Returning to Sport?	nan	UNKNOWN
The Role of Pyroptosis in Chronic Venous Disease	nan	UNKNOWN
Decoding the Inflammasome Influence on Treatment Response in Acute Myeloid Leukemia	nan	RECRUITING
Gluten-related Disorders in Familial Mediterranean Fever Patients	nan	COMPLETED
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1	nan	UNKNOWN
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a CASP1 binder may also engage these)

Protein	Name	Similarity
Q9MZV6	—	0.997	Q9MZV6 →
Q9MZV7	—	0.997	Q9MZV7 →
Q9N2I1	—	0.995	Q9N2I1 →
Q9TV13	—	0.992	Q9TV13 →
O75601	—	0.991	O75601 →
Q5E9C1	—	0.987	Q5E9C1 →
CASP4	Caspase-4	0.974	landscape →
P29452	—	0.969	P29452 →
P43527	—	0.967	P43527 →
Q075B4	—	0.953	Q075B4 →
CASP8	Caspase-8	0.952	landscape →
Q153Z0	—	0.952	Q153Z0 →
CASP12	Inactive caspase-12 (CASP-12)	0.942	landscape →
P70343	—	0.938	P70343 →
MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.935	landscape →
CASP6	Caspase-6	0.934	landscape →
CASP5	Caspase-5	0.933	landscape →
O15519	—	0.932	O15519 →
Q95ND5	—	0.930	Q95ND5 →
F1NV61	—	0.929	F1NV61 →
Q5XLA6	—	0.928	Q5XLA6 →
Q5RD56	—	0.927	Q5RD56 →
Q14246	—	0.926	Q14246 →
Q2TBA3	—	0.926	Q2TBA3 →
Q08DY9	—	0.926	Q08DY9 →
P97864	—	0.925	P97864 →
Q8MJU1	—	0.923	Q8MJU1 →
Q9H8W5	—	0.923	Q9H8W5 →
Q9JHX4	—	0.922	Q9JHX4 →
Q2PFV2	—	0.922	Q2PFV2 →