Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 7/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.81 |
| ▸ | TSHR | P16473 | 3/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.81 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | TCF4 | P15884 | 1/20 | 0.64 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573928 | 0.90 | CYP2C9 (0.82) | CYP2C9ALDH1A1TSHRNPSR1PKM | |
| SCHEMBL12787925 | 0.89 | CYP2C9 (1.00) | CYP2C9ALDH1A1TSHRNPSR1PKM | |
| SCHEMBL12787927 | 0.89 | CYP2C9 (0.81) | CYP2C9ALDH1A1TSHRNPSR1PKM | |
| SCHEMBL17331324 | 0.89 | CYP2C9 (0.80) | CYP2C9ALDH1A1TSHRNPSR1PKM | |
| SCHEMBL28560173 | 0.89 | CYP2C9 (0.80) | CYP2C9ALDH1A1TSHRNPSR1PKM | |
| SCHEMBL24102929 | 0.88 | CYP2C9 (0.79) | CYP2C9ALDH1A1TSHRNPSR1PKM | |
| SCHEMBL1071830 | 0.88 | CYP2C9 (0.79) | CYP2C9ALDH1A1TSHRNPSR1PKM | |
| SCHEMBL28556819 | 0.87 | CYP2C9 (0.77) | CYP2C9ALDH1A1TSHRNPSR1PKM | |
| SCHEMBL16119560 | 0.86 | CYP2C9 (0.76) | CYP2C9ALDH1A1TSHRNPSR1PKM | |
| SCHEMBL22391857 | 0.86 | CYP2C9 (0.76) | CYP2C9ALDH1A1TSHRNPSR1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230099912-A1 | BENZAMIDE COMPOUND AND PREPARATION METHOD, USE, AND PHARMACEUTICAL COMPOSITION THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2023-03-30 | — | — | US | disclosed |
| EP-3747866-B1 | BENZAMIDE COMPOUND AND PREPARATION METHOD, USE, AND PHARMACEUTICAL COMPOSITION THEREOF | INST MATERIA MEDICA CAMS (CN) | 2023-03-01 | — | — | EP | disclosed |
| US-11518744-B2 | Benzamide compound and preparation method, use, and pharmaceutical composition thereof | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2022-12-06 | — | — | US | disclosed |
| US-11518744-B2 | Benzamide compound and preparation method, use, and pharmaceutical composition thereof | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2022-12-06 | — | — | US | disclosed |
| WO-2021248256-A1 | PYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR, USE THEREOF AND PHARMACEUTICAL COMPOSITION THEREOF | 中国医学科学院药物研究所 | 2021-12-16 | — | — | WO | disclosed |
| US-20210047270-A1 | BENZAMIDE COMPOUND AND PREPARATION METHOD, USE, AND PHARMACEUTICAL COMPOSITION THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2021-02-18 | — | — | US | disclosed |
| US-20210047270-A1 | BENZAMIDE COMPOUND AND PREPARATION METHOD, USE, AND PHARMACEUTICAL COMPOSITION THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2021-02-18 | — | — | US | disclosed |
| EP-3747866-A1 | BENZAMIDE COMPOUND AND PREPARATION METHOD, USE, AND PHARMACEUTICAL COMPOSITION THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2020-12-09 | — | — | EP | disclosed |
| EP-3747866-A1 | BENZAMIDE COMPOUND AND PREPARATION METHOD, USE, AND PHARMACEUTICAL COMPOSITION THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2020-12-09 | — | — | EP | disclosed |
| WO-2019149223-A1 | BENZAMIDE COMPOUND AND PREPARATION METHOD, USE, AND PHARMACEUTICAL COMPOSITION THEREOF | 中国医学科学院药物研究所 | 2019-08-08 | — | — | WO | disclosed |
| WO-2019149223-A1 | BENZAMIDE COMPOUND AND PREPARATION METHOD, USE, AND PHARMACEUTICAL COMPOSITION THEREOF | 中国医学科学院药物研究所 | 2019-08-08 | — | — | WO | disclosed |
| US-20110060043-A1 | INHIBITORS OF CELL PROLIFERATION AND USES THEREOF | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2011-03-10 | — | — | US | disclosed |
| US-20110060043-A1 | INHIBITORS OF CELL PROLIFERATION AND USES THEREOF | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2011-03-10 | — | — | US | disclosed |
| US-20110060043-A1 | INHIBITORS OF CELL PROLIFERATION AND USES THEREOF | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2011-03-10 | — | — | US | disclosed |
| EP-2268613-A2 | INHIBITORS OF CELL PROLIFERATION AND USES THEREOF | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009106361-A2 | INHIBITORS OF CELL PROLIFERATION AND USES THEREOF | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106361-A2 | INHIBITORS OF CELL PROLIFERATION AND USES THEREOF | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230099912-A1 | BENZAMIDE COMPOUND AND PREPARATION METHOD, USE, AND PHARMACEUTICAL COMPOSITION THEREOF | JAK2, STAT3, STAT5A | CYP2C9 428/4885ALDH1A1 635/4885TSHR 506/4885 |
| US-20110060043-A1 | INHIBITORS OF CELL PROLIFERATION AND USES THEREOF | MKI67, CDKN1A, CCNI | CYP2C9 4747/4885ALDH1A1 2365/4885TSHR 3834/4885 |
| US-20210047270-A1 | BENZAMIDE COMPOUND AND PREPARATION METHOD, USE, AND PHARMACEUTICAL COMPOSITION THEREOF | JAK2, STAT3, STAT5A | CYP2C9 428/4885ALDH1A1 635/4885TSHR 506/4885 |
| US-11518744-B2 | Benzamide compound and preparation method, use, and pharmaceutical composition thereof | JAK2, STAT3, STAT5A | CYP2C9 428/4885ALDH1A1 635/4885TSHR 506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.