Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.64 |
| ▸ | RECQL | P46063 | 4/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | TEK | Q02763 | 1/20 | 0.64 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | RARB | P10826 | 1/20 | 0.55 |
| ▸ | RARG | P13631 | 1/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.55 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10735144 | 1.00 | KDM4E (0.64) | KDM4ERECQLTDP1HPGDPOLB | |
| SCHEMBL10740883 | 0.92 | PTGS1 (0.72) | KDM4ERECQLTDP1HPGDPOLB | |
| SCHEMBL10815465 | 0.92 | PTGS1 (0.72) | KDM4ERECQLTDP1HPGDPOLB | |
| SCHEMBL10740881 | 0.92 | PTGS1 (0.72) | KDM4ERECQLTDP1HPGDPOLB | |
| SCHEMBL11313191 | 0.91 | KDM4E (0.60) | KDM4ERECQLTDP1HPGDPOLB | |
| SCHEMBL11313189 | 0.91 | KDM4E (0.60) | KDM4ERECQLTDP1HPGDPOLB | |
| Carbenicillin Phenyl SCHEMBL150616 | 0.89 | KDM4E (0.68) | KDM4ERECQLTDP1HPGDPOLB | |
| Carbenicillin Phenyl SCHEMBL150615 | 0.89 | KDM4E (0.68) | KDM4ERECQLTDP1HPGDPOLB | |
| Carbenicillin Phenyl SCHEMBL10734854 | 0.89 | KDM4E (0.68) | KDM4ERECQLTDP1HPGDPOLB | |
| Carbenicillin Phenyl SCHEMBL11310099 | 0.89 | KDM4E (0.68) | KDM4ERECQLTDP1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0083977-A1 | 6-Alpha-hydroxymethylpenicillanic acid sulfone as a beta-lactamase inhibitor | PFIZER INC. (US) | 1983-07-20 | — | — | EP | claimed |
| EP-0008917-B1 | PENAM-3-CARBOXYLIC ACID 1,1-DIOXIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | PFIZER INC. (US) | 1982-11-24 | — | — | EP | claimed |
| US-4287181-A | TO ENHANCE THE EFFECTIVENESS OF B-LACTAM ANTIBIOTICS | PFIZER INC. (US) | 1981-09-01 | — | — | US | claimed |
| US-4256733-A | Acetoxymethyl penam compounds as β-lactamase inhibitors | PFIZER INC. (US) | 1981-03-17 | — | — | US | claimed |
| EP-0008917-A1 | Penam-3-carboxylic acid 1,1-dioxides, process for their preparation and pharmaceutical compositions | PFIZER INC. (US) | 1980-03-19 | — | — | EP | claimed |
| US-4656263-A | 6-β-substituted penicillanic acid compound free of the 6-α-epimer | PFIZER INC. (US) | 1987-04-07 | — | — | US | disclosed |
| EP-0095341-B1 | PENICILLANIC ACID DIOXIDE PRODRUG | PFIZER INC. (US) | 1986-02-26 | — | — | EP | disclosed |
| US-4518530-A | 6-β-Substituted penicillanic acids as β-lactamase inhibitors | PFIZER INC. (US) | 1985-05-21 | — | — | US | disclosed |
| US-4517126-A | Penicillanic acid derivative | PFIZER INC. (US) | 1985-05-14 | — | — | US | disclosed |
| US-4432970-A | SYNERGISTIC WITH AMINO ACID DERIVATIVE ANTIBIOTICS | PFIZER INC. (US) | 1984-02-21 | — | — | US | disclosed |
| US-4428935-A | BETA-LACTAMASE INHIBITORS | PFIZER INC. (US) | 1984-01-31 | — | — | US | disclosed |
| EP-0095341-A1 | Penicillanic acid dioxide prodrug | PFIZER INC. (US) | 1983-11-30 | — | — | EP | disclosed |
| US-4397783-A | HYDRODEHALOGENATION WITH AN ORGANOTIN HYDRIDE | PFIZER INC. (US) | 1983-08-09 | — | — | US | disclosed |
| EP-0083977-A1 | 6-Alpha-hydroxymethylpenicillanic acid sulfone as a beta-lactamase inhibitor | PFIZER INC. (US) | 1983-07-20 | — | — | EP | disclosed |
| EP-0008917-B1 | PENAM-3-CARBOXYLIC ACID 1,1-DIOXIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | PFIZER INC. (US) | 1982-11-24 | — | — | EP | disclosed |
| US-4287181-A | TO ENHANCE THE EFFECTIVENESS OF B-LACTAM ANTIBIOTICS | PFIZER INC. (US) | 1981-09-01 | — | — | US | disclosed |
| US-4256733-A | Acetoxymethyl penam compounds as β-lactamase inhibitors | PFIZER INC. (US) | 1981-03-17 | — | — | US | disclosed |
| US-4241050-A | Penam 1,1-dioxides as beta-lactamase inhibitors | PFIZER INC. (US) | 1980-12-23 | — | — | US | disclosed |
| US-4234579-A | Penicillanic acid 1,1-dioxides as β-lactamase inhibitors | PFIZER INC. (US) | 1980-11-18 | — | — | US | disclosed |
| EP-0008917-A1 | Penam-3-carboxylic acid 1,1-dioxides, process for their preparation and pharmaceutical compositions | PFIZER INC. (US) | 1980-03-19 | — | — | EP | disclosed |