SCHEMBL10736554

SCHEMBL10736554

Cc1cccc(OC(F)F)c1N(Cn1cccn1)C(=O)CCl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 3/20 0.42
ALDH1A1 P00352 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
CYP3A4 P08684 1/20 0.42
NLRP3 Q96P20 1/20 0.39
PDE4B Q07343 1/20 0.38
KAT7 O95251 1/20 0.35
KAT6B Q8WYB5 1/20 0.35
KAT6A Q92794 1/20 0.35
LMNA P02545 1/20 0.33
THRB P10828 1/20 0.33
HCRTR1 O43613 1/20 0.33
HCRTR2 O43614 1/20 0.33
NR1I2 O75469 1/20 0.33
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
KLKB1 P03952 2/20 0.32
CRHR1 P34998 1/20 0.32
IDH1 O75874 1/20 0.32
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10732053 0.90 TP53 (0.45) TP53ALDH1A1TDP1CYP3A4NLRP3
SCHEMBL10731615 0.88 TP53 (0.46) TP53ALDH1A1TDP1CYP3A4NLRP3
SCHEMBL10733944 0.88 PDE4B (0.37) TP53ALDH1A1TDP1CYP3A4NLRP3
SCHEMBL10729630 0.87 TP53 (0.40) TP53ALDH1A1TDP1CYP3A4NLRP3
SCHEMBL10736997 0.87 TP53 (0.42) TP53ALDH1A1TDP1CYP3A4NLRP3
Metazachlor SCHEMBL55016 0.86 TP53 (0.48) TP53ALDH1A1TDP1CYP3A4NLRP3
Metazachlor SCHEMBL4896537 0.86 TP53 (0.48) TP53ALDH1A1TDP1CYP3A4NLRP3
SCHEMBL10736975 0.86 TP53 (0.42) TP53ALDH1A1TDP1CYP3A4NLRP3
SCHEMBL10731298 0.85 TDP1 (0.41) TP53ALDH1A1TDP1CYP3A4NLRP3
SCHEMBL10736424 0.85 TP53 (0.50) TP53ALDH1A1TDP1CYP3A4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-61057540-A None JP disclosed
US-4659365-A Herbicidal 2-chloro-2'-fluoroalkoxyacetanilides MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1987-04-21 US disclosed
JP-S6157540-A NOVEL ACETANILIDE DERIVATIVE AND HERBICIDE CONTAINING SAME MITSUBISHI PETROCHEM CO LTD 1986-03-24 JP disclosed