Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 8/20 | 0.39 |
| ▸ | MGAM | O43451 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.39 |
| ▸ | SI | P14410 | 5/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.39 |
| ▸ | F2 | P00734 | 4/20 | 0.38 |
| ▸ | F10 | P00742 | 4/20 | 0.38 |
| ▸ | PLG | P00747 | 4/20 | 0.38 |
| ▸ | PLAU | P00749 | 4/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.38 |
| ▸ | PLAT | P00750 | 3/20 | 0.38 |
| ▸ | HPN | P05981 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10737627 | 0.87 | PDE5A (0.35) | PDE5APDE3BPDE3A | |
| SCHEMBL9634788 | 0.85 | AMY1A (0.38) | AMY1AMGAMGAASIMGAM2 | |
| SCHEMBL10742305 | 0.84 | PDE5A (0.47) | AMY1APDE5APDE3BPDE3A | |
| SCHEMBL10733507 | 0.81 | PDE5A (0.38) | AMY1AF2F10PLGPLAU | |
| SCHEMBL10740634 | 0.81 | AMY1A (0.41) | AMY1AMGAMGAASIMGAM2 | |
| SCHEMBL10737121 | 0.79 | AURKA (0.40) | GAA | |
| SCHEMBL10740355 | 0.79 | AMY1A (0.60) | AMY1AMGAMGAASIMGAM2 | |
| SCHEMBL10742034 | 0.77 | MEN1 (0.40) | MGAMGAASIMGAM2 | |
| SCHEMBL10739995 | 0.77 | PDE5A (0.34) | PDE5APDE3BPDE3A | |
| SCHEMBL10736276 | 0.77 | PDE5A (0.34) | PDE5APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4654344-A | ALSO AFFECT BLOOD PRESSURE AND MYOCARDIAL CONTRACTIONS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1987-03-31 | — | — | US | disclosed |
| EP-0093951-B1 | 2-ARYL-TETRAAZAINDENES | MERCK PATENT GmbH (DE) | 1986-10-29 | — | — | EP | disclosed |
| US-4575505-A | Pharmaceutical compositions containing 2-aryltetraazaindenes for treating ulcers or cardiac insufficiency or blood pressure abnormalities | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-03-11 | — | — | US | disclosed |
| US-4477454-A | INDOTROPIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-16 | — | — | US | disclosed |
| EP-0093951-A2 | 2-Aryl-tetraazaindenes | MERCK PATENT GmbH (DE) | 1983-11-16 | — | — | EP | disclosed |