Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | NPY1R | P25929 | 3/20 | 0.49 |
| ▸ | NPY2R | P49146 | 3/20 | 0.49 |
| ▸ | NPY4R | P50391 | 3/20 | 0.49 |
| ▸ | CCKBR | P32239 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24122290 | 0.87 | ECE1 (0.60) | NPY1RNPY2RNPY4RCCKBRKMT2A | |
| SCHEMBL23501894 | 0.87 | TRPV1 (0.64) | TRPV1FAAHPTGS2HTR1ANFKB1 | |
| SCHEMBL23501893 | 0.87 | TRPV1 (0.64) | TRPV1FAAHPTGS2HTR1ANFKB1 | |
| SCHEMBL5525292 | 0.86 | HTR1A (0.54) | NPY1RNPY2RNPY4RHTR1ANFKB1 | |
| SCHEMBL28314855 | 0.84 | TRPV1 (0.58) | TRPV1FAAHPTGS2HTR1ANFKB1 | |
| SCHEMBL28314856 | 0.84 | TRPV1 (0.58) | TRPV1FAAHPTGS2HTR1ANFKB1 | |
| SCHEMBL9664181 | 0.83 | MEN1 (0.64) | CCKBRKDM4EALDH1A1KMT2AECE1 | |
| SCHEMBL9664229 | 0.83 | MEN1 (0.62) | CCKBRKDM4EALDH1A1KMT2AECE1 | |
| SCHEMBL9664767 | 0.83 | MEN1 (0.62) | CCKBRKDM4EALDH1A1KMT2AECE1 | |
| SCHEMBL9664095 | 0.83 | MEN1 (0.62) | CCKBRKDM4EALDH1A1KMT2AECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4658038-A | N-acylated 5-hydroxytryptophan amide derivatives | RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (US) | 1987-04-14 | — | — | US | disclosed |
| US-4482567-A | N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics | RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. (US) | 1984-11-13 | — | — | US | disclosed |
| EP-0106281-A2 | Analgesia-effecting 5-hydroxytryptophan derivatives | YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) | 1984-04-25 | — | — | EP | disclosed |