Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10516031 | 0.93 | NPC1 (0.68) | NPC1RAB9ATP53MEN1KMT2A | |
| SCHEMBL10834365 | 0.93 | SIGMAR1 (0.64) | MEN1KMT2ASMN1; SMN2SIGMAR1 | |
| SCHEMBL10734444 | 0.91 | HRH3 (0.60) | NPC1RAB9ATP53MEN1KMT2A | |
| SCHEMBL10737009 | 0.89 | NPC1 (0.60) | NPC1RAB9ATP53MEN1KMT2A | |
| SCHEMBL8791480 | 0.83 | SIGMAR1 (0.52) | MEN1KMT2ASMN1; SMN2SIGMAR1TACR1 | |
| SCHEMBL10731913 | 0.82 | NPC1 (0.51) | NPC1RAB9ATP53MEN1KMT2A | |
| SCHEMBL10515031 | 0.81 | MAPK1 (0.70) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1727229 | 0.79 | BACE1 (0.65) | KDM4ESIGMAR1TACR1 | |
| SCHEMBL10730443 | 0.79 | S1PR1 (0.57) | NPC1RAB9ATP53MEN1KMT2A | |
| SCHEMBL493660 | 0.79 | SIGMAR1 (0.58) | MEN1KMT2ASMN1; SMN2ALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4650874-A | CARDIOVASCULAR AGENTS | G. D. SEARLE & CO. (US) | 1987-03-17 | — | — | US | disclosed |