Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | EDNRA | P25101 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 5/20 | 0.57 |
| ▸ | CA1 | P00915 | 5/20 | 0.57 |
| ▸ | CA2 | P00918 | 5/20 | 0.57 |
| ▸ | CA4 | P22748 | 5/20 | 0.57 |
| ▸ | CA9 | Q16790 | 5/20 | 0.57 |
| ▸ | PPARG | P37231 | 7/20 | 0.53 |
| ▸ | RXRA | P19793 | 5/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8431618 | 0.87 | CA2 (0.47) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL10740005 | 0.84 | CA12 (0.66) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL8521006 | 0.83 | CYP1A2 (0.82) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL5712301 | 0.78 | CYP1A2 (0.74) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL7927229 | 0.78 | CYP1A2 (0.74) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL5712302 | 0.78 | CYP1A2 (0.74) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL7929686 | 0.76 | CYP1A2 (0.59) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL8899525 | 0.74 | PPARG (0.50) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL7632658 | 0.74 | CYP1A2 (0.78) | CYP1A2MAPTMAPK1TDP1CYP3A4 | |
| SCHEMBL8899528 | 0.74 | PPARG (0.50) | CYP1A2MAPTMAPK1TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4656190-A | PLATELET ACTIVATING FACTOR | MERCK & CO., INC. (US) | 1987-04-07 | — | — | US | disclosed |
| EP-0142801-A2 | Indene derivatives useful as paf-antagonists | MERCK & CO. INC. (US) | 1985-05-29 | — | — | EP | disclosed |