Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10738569 | 0.90 | KMT2A (0.51) | RAB9AGSK3BKMT2ASTAT1MGAM | |
| SCHEMBL10731997 | 0.87 | KMT2A (0.43) | RAB9AKMT2ASTAT1LMNAALDH1A1 | |
| SCHEMBL10738872 | 0.87 | HSD17B10 (0.47) | RAB9AKMT2ASTAT1LMNAALDH1A1 | |
| SCHEMBL10733675 | 0.86 | PKM (0.49) | RAB9AKMT2ASTAT1MGAMAMY1A | |
| SCHEMBL10738470 | 0.86 | F2 (0.47) | RAB9AKMT2ASTAT1LMNAALDH1A1 | |
| SCHEMBL10733533 | 0.86 | POLB (0.55) | RAB9AGSK3BKMT2ASTAT1MGAM | |
| SCHEMBL10734700 | 0.83 | NPC1 (0.51) | RAB9AGSK3BKMT2AMGAMAMY1A | |
| SCHEMBL10734319 | 0.83 | KMT2A (0.42) | RAB9AKMT2ASTAT1LMNAALDH1A1 | |
| SCHEMBL10734718 | 0.83 | MAPT (0.46) | RAB9AGSK3BKMT2ASTAT1LMNA | |
| SCHEMBL10821523 | 0.83 | KMT2A (0.42) | RAB9AKMT2ASTAT1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4636509-A | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor | GLAXO GROUP LIMITED (GB) | 1987-01-13 | — | — | US | disclosed |
| EP-0044704-B1 | SUBSTITUTED PYRIMIDIN-2-ONES, THE SALTS THEREOF, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1986-05-07 | — | — | EP | disclosed |
| EP-0044704-A1 | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1982-01-27 | — | — | EP | disclosed |