Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8238436 | 0.84 | MAPK14 (0.52) | MAPK14CYP2C9KMT2ASMYD3GAA | |
| SCHEMBL1518227 | 0.80 | MAPK14 (0.44) | MAPK14CYP2C9KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1070915 | 0.77 | MEN1 (0.48) | MAPK14CYP2C9KMT2ASMN1; SMN2SMYD3 | |
| SCHEMBL10282601 | 0.76 | GLA (0.64) | MAPK14MAPK11CYP2C9HSPB1NPC1 | |
| SCHEMBL661051 | 0.75 | BRD4 (0.47) | MAPK14CYP2C9NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL89015 | 0.74 | CNR2 (0.55) | MAPK14CYP2C9NPC1RAB9AKMT2A | |
| SCHEMBL90498 | 0.74 | CNR2 (0.61) | MAPK14CYP2C9KMT2ATP53 | |
| SCHEMBL27973124 | 0.74 | ALDH1A1 (0.41) | RAB9AKMT2ATSHRALDH1A1GAA | |
| SCHEMBL2087745 | 0.73 | LRRK2 (0.49) | MAPK14RAB9AKMT2ARIPK2SMN1; SMN2 | |
| SCHEMBL27973149 | 0.73 | MEN1 (0.36) | MAPK14RAB9AKMT2ATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274295-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2011-01-19 | — | — | EP | disclosed |