Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10742755 | 0.93 | DRD2 (0.49) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL10745251 | 0.91 | DRD2 (0.48) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL10749274 | 0.89 | DRD2 (0.48) | DRD2DRD3DRD4KDM4ELMNA | |
| SCHEMBL10742344 | 0.89 | DRD2 (0.53) | DRD2DRD3DRD4KDM4ELMNA | |
| SCHEMBL10743376 | 0.89 | DRD2 (0.53) | DRD2DRD3DRD4KDM4ELMNA | |
| SCHEMBL10746245 | 0.88 | DRD2 (0.52) | DRD2DRD3DRD4 | |
| SCHEMBL10747820 | 0.88 | DRD2 (0.52) | DRD2DRD3DRD4 | |
| SCHEMBL10740975 | 0.88 | DRD2 (0.57) | DRD2DRD3DRD4MAPT | |
| SCHEMBL10745131 | 0.88 | DRD2 (0.54) | DRD2DRD3DRD4 | |
| SCHEMBL10742594 | 0.88 | DRD2 (0.57) | DRD2DRD3DRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4698351-A | Tetrahydrocarbazole derivatives and pharmaceutical compositions | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1987-10-06 | — | — | US | claimed |
| US-4618614-A | Method of treating psychosis using tetrahydrocarbazole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-21 | — | — | US | claimed |
| US-4698351-A | Tetrahydrocarbazole derivatives and pharmaceutical compositions | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1987-10-06 | — | — | US | disclosed |
| US-4618614-A | Method of treating psychosis using tetrahydrocarbazole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-21 | — | — | US | disclosed |
| US-4547576-A | Tetrahydrocarbazole derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-10-15 | — | — | US | disclosed |