Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 9/20 | 0.39 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652577 | 1.00 | MME (0.39) | MMEPYGLMALT1PPARG | |
| SCHEMBL653868 | 0.88 | MME (0.40) | MMEPPARG | |
| SCHEMBL650255 | 0.85 | MME (0.40) | MMEPYGLMALT1 | |
| SCHEMBL654691 | 0.85 | PPARG (0.48) | MMEPPARG | |
| SCHEMBL654692 | 0.85 | PPARG (0.48) | MMEPPARG | |
| SCHEMBL3771299 | 0.84 | PPARG (0.45) | PPARG | |
| SCHEMBL14119963 | 0.84 | MME (0.45) | MMEPYGLMALT1 | |
| SCHEMBL1077223 | 0.81 | MME (0.39) | MMEPYGLMALT1 | |
| SCHEMBL652027 | 0.81 | MME (0.39) | MMEPYGLMALT1 | |
| SCHEMBL652670 | 0.80 | AGTR2 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451782-A1 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005674-A1 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2011-01-13 | — | — | WO | disclosed |