⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69826 | 1.00 | — | — | |
| SCHEMBL3699619 | 0.97 | — | — | |
| SCHEMBL38786 | 0.97 | — | — | |
| SCHEMBL38727 | 0.88 | — | — | |
| SCHEMBL3705302 | 0.88 | — | — | |
| SCHEMBL25327994 | 0.81 | KMT2A (0.36) | — | |
| SCHEMBL13858690 | 0.81 | KMT2A (0.36) | — | |
| SCHEMBL542776 | 0.81 | KMT2A (0.36) | — | |
| SCHEMBL11594630 | 0.81 | KMT2A (0.36) | — | |
| SCHEMBL7340365 | 0.81 | KMT2A (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347572-A1 | AMINO ACIDS BEARING A TETRAZINE MOIETY | VALANX Biotech GmbH (AT) | 2024-04-10 | — | — | EP | claimed |
| US-20120184556-A1 | SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-07-19 | — | — | US | claimed |
| EP-2456310-A1 | SUBSTITUTED BENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | Vanderbilt University (US) | 2012-05-30 | — | — | EP | claimed |
| WO-2011011722-A1 | SUBSTITUTED BENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | VANDERBILT UNIVERSITY (US) | 2011-01-27 | — | — | WO | claimed |
| EP-4347572-A1 | AMINO ACIDS BEARING A TETRAZINE MOIETY | VALANX Biotech GmbH (AT) | 2024-04-10 | — | — | EP | disclosed |
| WO-2023163227-A1 | ANTIBODY-DRUG CONJUGATE | ＵＢＥ株式会社 | 2023-08-31 | — | — | WO | disclosed |
| WO-2023163234-A1 | ANTIBODY-DRUG CONJUGATE PRECURSOR AND INTERMEDIATE FOR SYNTHESIS THEREOF | ＵＢＥ株式会社 | 2023-08-31 | — | — | WO | disclosed |
| US-20230001024-A1 | CROSS-LINKING COMPOUNDS AND METHODS OF USE THEREOF | NORTH CAROLINA STATE UNIVERSITY | 2023-01-05 | — | — | US | disclosed |
| EP-4003363-A1 | CROSS-LINKING COMPOUNDS AND METHODS OF USE THEREOF | North Carolina State University (US) | 2022-06-01 | — | — | EP | disclosed |
| US-11242359-B2 | Biocompatible modular tetrazine platform | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2022-02-08 | — | — | US | disclosed |
| WO-2021016548-A1 | POLYIODIDE BINDING COMPOUNDS AND METHODS OF USE THEREOF | NORTH CAROLINA STATE UNIVERSITY (US) | 2021-01-28 | — | — | WO | disclosed |
| WO-2021016537-A1 | CROSS-LINKING COMPOUNDS AND METHODS OF USE THEREOF | NORTH CAROLINA STATE UNIVERSITY (US) | 2021-01-28 | — | — | WO | disclosed |
| US-20110294858-A1 | SUBSTITUTED 6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-12-01 | — | — | US | disclosed |
| WO-2011149963-A1 | SUBSTITUTED-6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | VANDERBILT UNIVERSITY (US) | 2011-12-01 | — | — | WO | disclosed |
| US-20110183980-A1 | O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-07-28 | — | — | US | disclosed |
| WO-2011087812-A1 | ALKYL 3-((2-AMIDOETHYL)AMINO)-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE ANALOGS AS SELECTIVE M1 AGONISTS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2011-07-21 | — | — | WO | disclosed |
| US-20110172227-A1 | ALKYL 3-((2-AMIDOETHYL)AMINO)-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE ANALOGS AS SELECTIVE M1 AGONISTS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY | 2011-07-14 | — | — | US | disclosed |
| WO-2011035324-A1 | O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |
| WO-2011029104-A1 | MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY (US) | 2011-03-10 | — | — | WO | disclosed |
| WO-2011011722-A1 | SUBSTITUTED BENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS | VANDERBILT UNIVERSITY (US) | 2011-01-27 | — | — | WO | disclosed |