Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1752852 | 0.85 | ACHE (0.56) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL1752885 | 0.83 | ACHE (0.62) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL1752857 | 0.80 | ACHE (0.68) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL1752803 | 0.80 | ACHE (0.58) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL1752884 | 0.79 | ACHE (0.57) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL1753027 | 0.77 | ACHE (0.48) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL2760423 | 0.76 | ACHE (0.64) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL14387221 | 0.76 | ACHE (0.52) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL10747649 | 0.76 | ACHE (0.59) | ACHELMNACYP3A4CYP1A2CYP2D6 | |
| SCHEMBL1753213 | 0.76 | ACHE (0.54) | ACHELMNACYP3A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4677106-A | ANTIDEPRESSANTS | SANOFI (FR) | 1987-06-30 | — | — | US | disclosed |
| US-4576946-A | ANTIDEPRESSANT | SANOFI (FR) | 1986-03-18 | — | — | US | disclosed |
| US-4514397-A | Derivatives of 4-methyl 6-phenyl pyridazine active on the central nervous system | SANOFI (FR) | 1985-04-30 | — | — | US | disclosed |