Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 13/20 | 0.60 |
| ▸ | ATP4B | P51164 | 13/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10750011 | 0.87 | MAPT (0.58) | ATP4AATP4B | |
| Bromide SCHEMBL10753076 | 0.82 | HDAC3 (0.65) | ATP4AATP4BHDAC3HDAC1HDAC2 | |
| Bromide SCHEMBL10749032 | 0.82 | HDAC3 (0.67) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| Bromide SCHEMBL10726966 | 0.81 | HDAC3 (0.69) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL10810745 | 0.81 | HDAC3 (0.66) | ATP4AATP4BHDAC3HDAC1HDAC2 | |
| SCHEMBL10812025 | 0.80 | HDAC3 (0.68) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL11148430 | 0.80 | HDAC3 (0.70) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| Bromide SCHEMBL10753066 | 0.79 | HDAC3 (0.57) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL10810738 | 0.78 | HDAC3 (0.58) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| Bromide SCHEMBL827268 | 0.76 | ATP4A (1.00) | ATP4AATP4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4645841-A | ANTIULCER AGENTS | ISTITUTO DE ANGELI, S.P.A. (IT) | 1987-02-24 | — | — | US | disclosed |
| US-4548944-A | ANTIULCER, ANTISECRETORY AGENTS | ISTITUTO DE ANGELI S.P.A. (IT) | 1985-10-22 | — | — | US | disclosed |