Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CPA1 | P15085 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823270 | 0.75 | GRIK1 (0.41) | GRIK1GRIK2CYP2C19CPA1 | |
| SCHEMBL10340456 | 0.75 | GRIK1 (0.32) | GRIK1GRIK2CYP2C19CPA1 | |
| SCHEMBL6495395 | 0.72 | ALDH1A1 (0.31) | GRIK1GRIK2 | |
| SCHEMBL3366902 | 0.72 | TSHR (0.50) | GRIK1GRIK2 | |
| SCHEMBL6497512 | 0.72 | ALDH1A1 (0.31) | GRIK1GRIK2 | |
| SCHEMBL6495386 | 0.72 | ALDH1A1 (0.31) | GRIK1GRIK2 | |
| SCHEMBL2143209 | 0.70 | — | — | |
| SCHEMBL1723945 | 0.70 | — | — | |
| SCHEMBL9275517 | 0.70 | — | — | |
| SCHEMBL8523299 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4645838-A | Pyrazolopyridine compounds, and intermediates, useful as anxiolytic agents | ICI AMERICAS INC. (US) | 1987-02-24 | — | — | US | disclosed |
| US-4563525-A | Process for preparing pyrazolopyridine compounds | ICI AMERICAS INC. (US) | 1986-01-07 | — | — | US | disclosed |
| EP-0076035-B1 | PYRAZOLO(3,4-B)PYRIDINE DERIVATIVES | ICI AMERICAS INC. (US) | 1985-12-11 | — | — | EP | disclosed |
| US-4552883-A | CNS DEPRESSANTS, ANXIOLYTICS | ICI AMERICAS INC. (US) | 1985-11-12 | — | — | US | disclosed |
| US-4511568-A | CNS-Depressant pyrazolopyridines | ICI AMERICAS INC. (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0096995-A2 | Pyrazolopyridine compounds | ICI AMERICAS INC. (US) | 1983-12-28 | — | — | EP | disclosed |
| EP-0094175-A1 | Pyrazolopyridine compounds | ICI AMERICAS INC. (US) | 1983-11-16 | — | — | EP | disclosed |
| EP-0076035-A1 | Pyrazolo(3,4-b)pyridine derivatives | ICI AMERICAS INC. (US) | 1983-04-06 | — | — | EP | disclosed |
| US-4364948-A | Pyrazolo[3,4-b]pyridine compounds | ICI AMERICAS INC. (US) | 1982-12-21 | — | — | US | disclosed |