Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HRH2 | P25021 | 6/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lavoltidine SCHEMBL1142 | 0.97 | SMN1; SMN2 (0.55) | SMN1; SMN2TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11010882 | 0.97 | SMN1; SMN2 (0.55) | SMN1; SMN2TP53CYP1A2CYP3A4CYP2D6 | |
| Lavoltidine SCHEMBL30095469 | 0.97 | SMN1; SMN2 (0.55) | SMN1; SMN2TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11106320 | 0.97 | SMN1; SMN2 (0.55) | SMN1; SMN2TP53CYP1A2CYP3A4CYP2D6 | |
| Acetic Acid SCHEMBL11011722 | 0.96 | HRH2 (0.52) | SMN1; SMN2TP53CYP1A2CYP3A4CYP2D6 | |
| Lavoltidine SCHEMBL633369 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11100251 | 0.91 | TP53 (0.47) | SMN1; SMN2TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11014531 | 0.91 | HRH2 (0.53) | SMN1; SMN2TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10750320 | 0.91 | TP53 (0.52) | SMN1; SMN2TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4607091 | 0.90 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016565-B1 | 1,2,4-TRIAZOLE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1984-05-23 | — | — | EP | claimed |
| EP-0016565-A1 | 1,2,4-Triazole derivatives, processes for their production and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1980-10-01 | — | — | EP | claimed |
| US-4670448-A | ANTIINFLAMMATORY AGENTS, HISTAMINE H2-ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1987-06-02 | — | — | US | disclosed |
| US-4536508-A | ANTIALLERGENS AND ANTIINFLAMMATORY AGENTS | GLAXO GROUP LIMITED (GB) | 1985-08-20 | — | — | US | disclosed |
| EP-0016565-B1 | 1,2,4-TRIAZOLE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1984-05-23 | — | — | EP | disclosed |
| EP-0016565-A1 | 1,2,4-Triazole derivatives, processes for their production and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1980-10-01 | — | — | EP | disclosed |