⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydantoin SCHEMBL27690 | 0.97 | — | — | |
| Hydantoin SCHEMBL7285865 | 0.97 | — | — | |
| Hydantoin SCHEMBL27705088 | 0.97 | CRBN (0.52) | — | |
| Hydantoin SCHEMBL11595715 | 0.94 | CRBN (0.50) | — | |
| Hydantoin SCHEMBL22371823 | 0.94 | — | — | |
| Hydantoin SCHEMBL8638709 | 0.94 | — | — | |
| Hydantoin SCHEMBL3243764 | 0.94 | — | — | |
| Hydantoin SCHEMBL21352289 | 0.94 | — | — | |
| Hydantoin SCHEMBL10578146 | 0.94 | — | — | |
| Hydantoin SCHEMBL10408014 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240092755-A1 | SPIROHEPTANYL HYDANTOINS AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2024-03-21 | — | — | US | disclosed |
| CN-110914257-B | Spiroheptylhydantoins as ROCK inhibitors | 百时美施贵宝公司 | 2023-05-26 | — | — | CN | disclosed |
| EP-3652167-B1 | SPIROHEPTANYL HYDANTOINS AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-06-02 | — | — | EP | disclosed |
| US-20210155618-A1 | SPIROHEPTANYL HYDANTOINS AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-05-27 | — | — | US | disclosed |
| CN-110914257-A | Spiroheptyl hydantoins as ROCK inhibitors | 百时美施贵宝公司 | 2020-03-24 | — | — | CN | disclosed |
| US-4684736-A | Bisimidazolium salts | CIBA-GEIGY CORPORATION (US) | 1987-08-04 | — | — | US | disclosed |