Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.62 |
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10757258 | 1.00 | LOXL2 (0.62) | LOXL2HRH1FERMT2NCF1HTR1A | |
| SCHEMBL14157416 | 1.00 | LOXL2 (0.62) | LOXL2HRH1FERMT2NCF1HTR1A | |
| SCHEMBL4870416 | 0.98 | LOXL2 (0.65) | LOXL2HRH1FERMT2NCF1HTR1A | |
| SCHEMBL336172 | 0.93 | LOXL2 (0.67) | LOXL2HRH1FERMT2NCF1HTR1A | |
| SCHEMBL2333461 | 0.91 | LOXL2 (0.62) | LOXL2FERMT2NCF1HTR1AADRA1D | |
| SCHEMBL2331919 | 0.91 | LOXL2 (0.62) | LOXL2FERMT2NCF1HTR1AADRA1D | |
| SCHEMBL6223283 | 0.85 | LOXL2 (0.71) | LOXL2HRH1FERMT2NCF1HTR1A | |
| Hydrochloric Acid SCHEMBL20592932 | 0.84 | LOXL2 (0.69) | LOXL2HRH1FERMT2NCF1HTR1A | |
| SCHEMBL6114811 | 0.83 | LOXL2 (0.53) | LOXL2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL16289396 | 0.83 | LOXL2 (0.53) | LOXL2FERMT2NCF1HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4680300-A | PSORIASIS | SYNTEX (U.S.A.) INC. (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0188333-A1 | Anti-inflammatory guanidines, their preparation and compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1986-07-23 | — | — | EP | disclosed |