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Sugi Predict / Targets / LOXL2

LOXL2

Lysyl oxidase homolog 2 · Q9Y4K0 · LOXL2 on Sugi Atlas →

76,237 patent compounds predicted against LOXL2, 40,991 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Thiazolsulfone Thiazolsulfone (SCHEMBL152559) 0.49 9/20
SCHEMBL15828 SCHEMBL15828 0.73 7/20
SCHEMBL111287 SCHEMBL111287 0.48 7/20
SCHEMBL69667 SCHEMBL69667 0.59 6/20
SCHEMBL69668 SCHEMBL69668 0.59 6/20
SCHEMBL74590 SCHEMBL74590 0.55 6/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL154002) 0.95 5/20
SCHEMBL36008 SCHEMBL36008 0.71 5/20
SCHEMBL130180 SCHEMBL130180 0.67 5/20
SCHEMBL171386 SCHEMBL171386 0.64 5/20
SCHEMBL61226 SCHEMBL61226 0.62 5/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL161528) 0.52 5/20
SCHEMBL100121 SCHEMBL100121 0.52 5/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL158931) 0.51 5/20
SCHEMBL112429 SCHEMBL112429 0.45 5/20
SCHEMBL17342 SCHEMBL17342 0.67 4/20
SCHEMBL17752 SCHEMBL17752 0.67 4/20
SCHEMBL102047 SCHEMBL102047 0.62 4/20
Aminomethylbenzoic Acid Aminomethylbenzoic Acid (SCHEMBL38758) 0.57 4/20
SCHEMBL40545 SCHEMBL40545 0.53 4/20

Clinical trials — most relevant to LOXL2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Predicting Response to Standardized Pediatric Colitis Therapy PHASE4COMPLETED
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency PHASE3COMPLETED
Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci) PHASE2COMPLETED
Open Label, Dose Escalation Study for the Safety and Efficacy of STP705 in Adult Patients With Basal Cell Carcinoma PHASE2COMPLETED
GSK2190915 Neutrophilic Asthma Study PHASE2COMPLETED
Endometriosis and Microvascular Dysfunction: Role of Inflammation EARLY_PHASE1RECRUITING
A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjects With Scleroderma nanCOMPLETED
Pelvic Organs Prolapse Treatment Using Neodymium Laser nanACTIVE_NOT_RECRUITING
Multi-Analyte, Genetic, and Thrombogenic Markers of Atherosclerosis nanUNKNOWN
In Vitro Demonstration of Direct Platelet-Related Effects of PCSK9 Enzyme nanNOT_YET_RECRUITING
Gene Expression in Chronic Venous Leg Ulcers nanUNKNOWN
Role of Metabolic Enzymes in Non-Melanoma Skin Cancer nanCOMPLETED
Genetic Testing to Understand and Address Renal Disease Disparities nanCOMPLETED
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes nanRECRUITING
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects) nanUNKNOWN
Biomarkers of Lichen Sclerosus nanUNKNOWN
Inflammatory Genomics in Human Carotid Artery Disease nanCOMPLETED
Genetic Analysis of Keloids nanRECRUITING
Genetic Study of Age-Related Macular Degeneration nanCOMPLETED
LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients nanACTIVE_NOT_RECRUITING
Gene First Approach to Connective Tissue Disease nanCOMPLETED
Chronic Kidney Disease : Role of Biological Factors and Apolipoprotein L1 Encoding Gene (APOL1) nanCOMPLETED
for Adipose Tissue DIabetes VAriants (fATDIVA) nanCOMPLETED
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection nanUNKNOWN
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults nanCOMPLETED
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST) nanCOMPLETED
Exome Evaluation in Patients Living With Diabetes Complicated by Charcot Neuroarthropathy. nanCOMPLETED
The Genetics of Environmental Asthma nanCOMPLETED
Microarray Analysis of Gene Expression in Idiopathic Pulmonary Fibrosis (IPF) nanACTIVE_NOT_RECRUITING
Identification of a New Gene Involved in Hereditary Lipodystrophy nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a LOXL2 binder may also engage these)

ProteinNameSimilarity
Q5RFQ6 — 1.000 Q5RFQ6 →
B4F6N6 — 1.000 B4F6N6 →
A6H737 — 1.000 A6H737 →
E1C3U7 — 1.000 E1C3U7 →
P58022 — 1.000 P58022 →
A1L1V4 — 1.000 A1L1V4 →
Q08B63 — 1.000 Q08B63 →
B8A4W9 — 1.000 B8A4W9 →
B5DF27 — 1.000 B5DF27 →
F1RD85 — 0.999 F1RD85 →
F1QQC3 — 0.999 F1QQC3 →
Q9Z175 — 0.998 Q9Z175 →
LOXL3 Lysyl oxidase homolog 3 0.997 landscape →
Q924C6 — 0.995 Q924C6 →
Q5G265 — 0.993 Q5G265 →
P16264 — 0.992 P16264 →
Q5G270 — 0.991 Q5G270 →
Q9WUW3 — 0.991 Q9WUW3 →
Q5G266 — 0.990 Q5G266 →
Q8MJ24 — 0.990 Q8MJ24 →
Q93105 — 0.990 Q93105 →
O73798 — 0.989 O73798 →
Q5G268 — 0.989 Q5G268 →
P41245 — 0.989 P41245 →
Q95220 — 0.989 Q95220 →
Q5RB02 — 0.989 Q5RB02 →
Q9WTR0 — 0.989 Q9WTR0 →
Q9VGY6 — 0.989 Q9VGY6 →
O18016 — 0.989 O18016 →
P53690 — 0.989 P53690 →