Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 7/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.43 |
| ▸ | MME | P08473 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653067 | 1.00 | AGTR2 (0.43) | AGTR2AGTR1MME | |
| SCHEMBL656488 | 0.92 | AGTR2 (0.50) | AGTR2 | |
| SCHEMBL652670 | 0.92 | AGTR2 (0.42) | AGTR2AGTR1 | |
| SCHEMBL1074430 | 0.91 | AGTR2 (0.46) | AGTR2 | |
| SCHEMBL652689 | 0.91 | AGTR2 (0.46) | AGTR2 | |
| SCHEMBL653073 | 0.91 | AGTR2 (0.45) | AGTR2AGTR1 | |
| SCHEMBL994431 | 0.91 | AGTR2 (0.45) | AGTR2AGTR1 | |
| SCHEMBL650451 | 0.90 | AGTR2 (0.41) | AGTR2AGTR1 | |
| SCHEMBL650654 | 0.90 | AGTR2 (0.43) | AGTR2AGTR1 | |
| SCHEMBL656868 | 0.90 | AGTR2 (0.43) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451782-A1 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005674-A1 | DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2011-01-13 | — | — | WO | disclosed |