Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.59 |
| ▸ | DRD3 | P35462 | 12/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 6/20 | 0.51 |
| ▸ | DRD4 | P21917 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 4/20 | 0.50 |
| ▸ | DRD1 | P21728 | 2/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10761212 | 0.99 | DRD2 (0.57) | DRD2DRD3FYNHTR1ADRD4 | |
| SCHEMBL10761230 | 0.84 | DRD2 (0.66) | DRD2DRD3FYNHTR1AHTR1D | |
| SCHEMBL10758705 | 0.83 | DRD3 (0.60) | DRD2DRD3FYNHTR1ADRD4 | |
| SCHEMBL10761186 | 0.83 | DRD2 (0.60) | DRD2DRD3FYNHTR1A | |
| Hydrochloric Acid SCHEMBL10763527 | 0.83 | DRD2 (0.64) | DRD2DRD3FYNHTR1AHTR1D | |
| SCHEMBL10755730 | 0.82 | DRD2 (0.62) | DRD2DRD3FYNHTR1AHTR1D | |
| SCHEMBL10762873 | 0.82 | DRD2 (0.56) | DRD2DRD3FYNHTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL10850176 | 0.81 | DRD2 (0.61) | DRD2DRD3FYNHTR1A | |
| Bromide SCHEMBL10759133 | 0.81 | DRD2 (0.55) | DRD2DRD3FYNHTR1AMEN1 | |
| SCHEMBL10762864 | 0.81 | DRD3 (0.55) | DRD2DRD3FYNHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209983-A1 | Dialkylaminotetrahydroquinazoline | ELI LILLY AND COMPANY (US) | 1987-01-28 | — | — | EP | disclosed |
| US-4622398-A | INCREASING CONCENTRATION OF DOPAMINE AND NOREPINEPHRINE IN BRAIN, ANTAGONIST | ELI LILLY AND COMPANY (US) | 1986-11-11 | — | — | US | disclosed |