Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.57 |
| ▸ | JAK2 | O60674 | 8/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1077041 | 0.81 | NTRK1 (0.56) | NTRK1JAK2HTR2AKCNH2KDM4E | |
| SCHEMBL16429312 | 0.80 | JAK2 (0.55) | NTRK1JAK2HTR2AKCNH2HTR2C | |
| SCHEMBL28673945 | 0.77 | NTRK1 (0.46) | NTRK1JAK2HTR2AHTR2C | |
| SCHEMBL28673947 | 0.77 | NTRK1 (0.46) | NTRK1JAK2HTR2AHTR2C | |
| SCHEMBL4102308 | 0.76 | JAK2 (0.52) | NTRK1JAK2HTR2AKCNH2HTR2C | |
| Hydrochloric Acid SCHEMBL933544 | 0.73 | NTRK1 (0.88) | NTRK1JAK2 | |
| Hydrochloric Acid SCHEMBL933542 | 0.73 | NTRK1 (0.88) | NTRK1JAK2 | |
| SCHEMBL2692528 | 0.73 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL2692531 | 0.73 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL19547456 | 0.72 | NTRK1 (0.83) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011006074-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-01-13 | — | — | WO | disclosed |