Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.46 |
| ▸ | JAK2 | O60674 | 6/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.37 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28673947 | 1.00 | NTRK1 (0.46) | NTRK1JAK2JAK1CCNT1CDK9 | |
| SCHEMBL19547195 | 0.78 | NTRK1 (0.47) | NTRK1JAK2HTR2CHTR2ASLC6A2 | |
| SCHEMBL19547181 | 0.78 | NTRK1 (0.49) | NTRK1JAK2HTR2CHTR2ASLC6A2 | |
| SCHEMBL1075466 | 0.77 | NTRK1 (0.57) | NTRK1JAK2HTR2CHTR2A | |
| SCHEMBL15017378 | 0.76 | NTRK1 (0.42) | NTRK1JAK2CCNT1CDK9 | |
| SCHEMBL21097327 | 0.76 | NTRK1 (0.42) | NTRK1JAK2CCNT1CDK9 | |
| SCHEMBL28673955 | 0.75 | NTRK1 (0.50) | NTRK1JAK2 | |
| SCHEMBL28072182 | 0.75 | NTRK1 (0.50) | NTRK1JAK2 | |
| SCHEMBL19547157 | 0.74 | NTRK1 (0.50) | NTRK1JAK2HTR2CHTR2ASLC6A2 | |
| SCHEMBL28663932 | 0.72 | MAPT (0.52) | NTRK1JAK2CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003214-B | Substituted pyrazolo [1,5-a ] pyrimidine compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-106008523-A | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | 阵列生物制药公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-102596957-B | Substituted pyrazolo [1,5-a ] pyrimidine compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2016-06-29 | — | — | CN | disclosed |