Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.39 |
| ▸ | PDE4A | P27815 | 5/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.39 |
| ▸ | NEK2 | P51955 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846641 | 0.87 | CHEK1 (0.68) | CDK2CCNA1CHEK1CCNA2SRC | |
| SCHEMBL1023295 | 0.85 | PDE4D (0.42) | CDK2CCNA1CHEK1CCNA2PDE10A | |
| SCHEMBL585004 | 0.85 | CDK2 (0.51) | CDK2CCNA1CHEK1CCNA2SRC | |
| SCHEMBL10236643 | 0.85 | CDK2 (0.51) | CDK2CCNA1CHEK1CCNA2SRC | |
| SCHEMBL16086901 | 0.84 | PDE10A (0.48) | CDK2CCNA1CHEK1CCNA2PDE10A | |
| SCHEMBL593655 | 0.83 | CDK2 (0.54) | CDK2CCNA1CHEK1CCNA2SRC | |
| SCHEMBL6890507 | 0.82 | CDK2 (0.48) | CDK2CCNA1CHEK1CCNA2SRC | |
| SCHEMBL10277723 | 0.82 | CDK2 (0.48) | CDK2CCNA1CHEK1CCNA2SRC | |
| SCHEMBL10236616 | 0.81 | CDK2 (0.49) | CDK2CCNA1CHEK1CCNA2SRC | |
| SCHEMBL584858 | 0.80 | CHEK1 (0.59) | CDK2CCNA1CHEK1CCNA2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448942-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | Schering Corporation (US) | 2012-05-09 | — | — | EP | disclosed |
| WO-2012027240-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |