Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.68 |
| ▸ | CDK2 | P24941 | 6/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.68 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.68 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 7/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.37 |
| ▸ | CDK7 | P50613 | 3/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCND1 | P24385 | 2/20 | 0.37 |
| ▸ | CCNH | P51946 | 2/20 | 0.37 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30758 | 0.89 | CHEK1 (0.60) | CHEK1CDK2CCNA2CCNA1PDE10A | |
| SCHEMBL20974 | 0.88 | CHEK1 (0.59) | CHEK1CDK2CCNA2CCNA1PDE10A | |
| SCHEMBL584858 | 0.88 | CHEK1 (0.59) | CHEK1CDK2CCNA2CCNA1PDE10A | |
| SCHEMBL1075532 | 0.87 | CDK2 (0.55) | CHEK1CDK2CCNA2CCNA1PDE10A | |
| SCHEMBL583997 | 0.84 | CHEK1 (0.55) | CHEK1CDK2CCNA2CCNA1PDE10A | |
| SCHEMBL593655 | 0.83 | CDK2 (0.54) | CHEK1CDK2CCNA2CCNA1PDE10A | |
| SCHEMBL10236643 | 0.83 | CDK2 (0.51) | CHEK1CDK2CCNA2CCNA1PDE10A | |
| SCHEMBL585004 | 0.83 | CDK2 (0.51) | CHEK1CDK2CCNA2CCNA1PDE10A | |
| SCHEMBL583804 | 0.82 | CHEK1 (0.56) | CHEK1CDK2CCNA2CCNA1PDE10A | |
| SCHEMBL21498 | 0.82 | CDK2 (0.53) | CHEK1CDK2CCNA2CCNA1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |