Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.54 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7635745 | 0.93 | TDP1 (0.47) | TDP1MMP8TSHRMAPK1L3MBTL1 | |
| SCHEMBL7637377 | 0.80 | KMT2A (0.49) | MMP8TSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL7644647 | 0.80 | TDP1 (0.46) | TDP1MMP8TSHRPIN1KMT2A | |
| SCHEMBL7638616 | 0.79 | KMT2A (0.43) | MMP8TSHRALDH1A1PIN1KMT2A | |
| SCHEMBL7634125 | 0.79 | ALDH1A1 (0.47) | TDP1TSHRMAPK1L3MBTL1ALDH1A1 | |
| SCHEMBL7636094 | 0.79 | AOC3 (0.41) | TDP1TSHRL3MBTL1ALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL7770451 | 0.78 | TDP1 (0.54) | TDP1MMP8TSHRMAPK1L3MBTL1 | |
| SCHEMBL7640630 | 0.77 | TSHR (0.39) | TSHRALDH1A1KMT2AMEN1POLB | |
| SCHEMBL7640821 | 0.76 | TDP1 (0.51) | TDP1MMP8PIN1KMT2AMEN1 | |
| SCHEMBL9559495 | 0.75 | KMT2A (0.45) | MMP8TSHRALDH1A1PIN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4672071-A | Antihypertensive dihydropyridine compositions, optical isomers and intermediates | SYNTEX (U.S.A.) INC. (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0191448-A2 | Antihypertensive dihydropyridine derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-08-20 | — | — | EP | disclosed |
| US-4595690-A | Hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1986-06-17 | — | — | US | disclosed |