Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | DHODH | Q02127 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | TACR3 | P29371 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10758382 | 0.91 | TSHR (0.67) | MAPTTSHRDHODHKDM4EHPGD | |
| SCHEMBL10758695 | 0.89 | KDM4E (0.61) | MAPTTP53TSHRDHODHKDM4E | |
| SCHEMBL10757131 | 0.89 | ALDH1A1 (0.64) | MAPTDHODHKDM4EHPGDALDH1A1 | |
| SCHEMBL10761066 | 0.88 | ALDH1A1 (0.56) | MAPTTSHRDHODHKDM4EHPGD | |
| SCHEMBL10763633 | 0.88 | MAPT (0.56) | MAPTTP53TSHRDHODHKDM4E | |
| SCHEMBL10762912 | 0.88 | TSHR (0.57) | MAPTTSHRDHODHKDM4EHPGD | |
| SCHEMBL10761891 | 0.86 | KDM4E (0.74) | MAPTTP53THRBKDM4EHPGD | |
| SCHEMBL10390278 | 0.83 | ABL1 (0.58) | MAPTTP53THRBTSHRDHODH | |
| SCHEMBL17413273 | 0.83 | TSHR (0.60) | MAPTTSHRDHODHKDM4EHPGD | |
| SCHEMBL10761658 | 0.83 | MEN1 (0.54) | MAPTTSHRKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711890-A | TREATMENT OF ANXIETY STATES OR OF PULMONARY, RENAL, CIRCULATORY OF CARDIOVASCULAR DISORDERS | RHONE-POULENC SANTE (FR) | 1987-12-08 | — | — | US | disclosed |
| US-4684652-A | TREATING ANXIETY OR CARDIOVASCULAR DISORDERS | RHONE-POULENC SANTE (FR) | 1987-08-04 | — | — | US | disclosed |