Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10759878 | 1.00 | CA2 (0.40) | CA2NAMPTTMEM97SIGMAR1SPHK1 | |
| SCHEMBL10758894 | 1.00 | CA2 (0.40) | CA2NAMPTTMEM97SIGMAR1SPHK1 | |
| SCHEMBL10757112 | 0.87 | TMEM97 (0.36) | CA2NAMPTTMEM97SIGMAR1P2RX3 | |
| SCHEMBL10754804 | 0.87 | TMEM97 (0.36) | CA2NAMPTTMEM97SIGMAR1P2RX3 | |
| SCHEMBL10755417 | 0.85 | TMEM97 (0.34) | CA2NAMPTTMEM97SIGMAR1P2RX3 | |
| SCHEMBL10753422 | 0.82 | SMN1; SMN2 (0.45) | CA2NAMPTTMEM97SIGMAR1KDM4E | |
| SCHEMBL10760974 | 0.82 | SMN1; SMN2 (0.45) | CA2NAMPTTMEM97SIGMAR1KDM4E | |
| SCHEMBL10753411 | 0.82 | SMN1; SMN2 (0.45) | CA2NAMPTTMEM97SIGMAR1KDM4E | |
| SCHEMBL10758430 | 0.80 | SMN1; SMN2 (0.46) | CA2NAMPTTMEM97SIGMAR1ALDH1A1 | |
| SCHEMBL10759549 | 0.78 | CA2 (0.40) | CA2NAMPTTMEM97SIGMAR1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4672071-A | Antihypertensive dihydropyridine compositions, optical isomers and intermediates | SYNTEX (U.S.A.) INC. (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0191448-A2 | Antihypertensive dihydropyridine derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-08-20 | — | — | EP | disclosed |
| US-4595690-A | Hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1986-06-17 | — | — | US | disclosed |