Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.71 |
| ▸ | THPO | P40225 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.71 |
| ▸ | CACNA1F | O60840 | 6/20 | 0.70 |
| ▸ | CACNA1D | Q01668 | 6/20 | 0.70 |
| ▸ | CACNA1S | Q13698 | 6/20 | 0.70 |
| ▸ | CACNA1C | Q13936 | 6/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10756624 | 0.95 | CYP1A2 (0.74) | MEN1KMT2AHIF1AMAPTCYP1A2 | |
| SCHEMBL9712629 | 0.93 | MAPT (0.77) | MEN1KMT2AHIF1AMAPTCYP1A2 | |
| SCHEMBL10758957 | 0.90 | MEN1 (0.75) | MEN1KMT2AHIF1AMAPTCYP1A2 | |
| Water SCHEMBL10650907 | 0.90 | CACNA1F (0.76) | MEN1KMT2AHIF1AMAPTCYP1A2 | |
| SCHEMBL10759897 | 0.88 | MAPT (0.65) | MEN1KMT2AHIF1AMAPTCYP1A2 | |
| SCHEMBL10760860 | 0.88 | MEN1 (0.65) | MEN1KMT2AHIF1AMAPTCYP1A2 | |
| SCHEMBL9476417 | 0.88 | MEN1 (0.84) | MEN1KMT2AHIF1AMAPTCYP1A2 | |
| SCHEMBL10758556 | 0.87 | CYP1A2 (0.74) | MEN1KMT2AHIF1AMAPTCYP1A2 | |
| SCHEMBL10758893 | 0.87 | CACNA1F (0.75) | MEN1KMT2AHIF1AMAPTCYP1A2 | |
| SCHEMBL10686282 | 0.87 | CACNA1F (0.67) | MEN1KMT2AHIF1AMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4672071-A | Antihypertensive dihydropyridine compositions, optical isomers and intermediates | SYNTEX (U.S.A.) INC. (US) | 1987-06-09 | — | — | US | disclosed |
| EP-0191448-A2 | Antihypertensive dihydropyridine derivatives | SYNTEX (U.S.A.) INC. (US) | 1986-08-20 | — | — | EP | disclosed |
| US-4595690-A | Hypotensive agents | SYNTEX (U.S.A.) INC. (US) | 1986-06-17 | — | — | US | disclosed |