Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.77 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.75 |
| ▸ | LMNA | P02545 | 4/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.75 |
| ▸ | TSHR | P16473 | 3/20 | 0.75 |
| ▸ | NPC1 | O15118 | 1/20 | 0.75 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.75 |
| ▸ | PGR | P06401 | 1/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.75 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.75 |
| ▸ | HTR1A | P08908 | 1/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11739916 | 0.94 | MAPT (0.80) | MAPTMEN1KMT2ATDP1CACNA1C | |
| SCHEMBL10759264 | 0.93 | MEN1 (0.71) | MAPTMEN1KMT2ATDP1CACNA1C | |
| SCHEMBL7272403 | 0.91 | MAPT (0.68) | MAPTMEN1KMT2ATDP1CACNA1C | |
| SCHEMBL3681361 | 0.90 | MAPT (0.85) | MAPTMEN1KMT2ATDP1CACNA1C | |
| SCHEMBL10759897 | 0.90 | MAPT (0.65) | MAPTMEN1KMT2ATDP1CACNA1C | |
| Monoethanolamine SCHEMBL10892805 | 0.89 | MAPT (0.73) | MAPTMEN1KMT2ATDP1CACNA1C | |
| Hydrochloric Acid SCHEMBL1495251 | 0.89 | MAPT (0.84) | MAPTMEN1KMT2ATDP1CACNA1C | |
| SCHEMBL9476417 | 0.89 | MEN1 (0.84) | MAPTMEN1KMT2ATDP1CACNA1C | |
| SCHEMBL9765708 | 0.89 | MAPT (0.74) | MAPTMEN1KMT2ATDP1CACNA1C | |
| SCHEMBL10882908 | 0.89 | HIF1A (0.76) | MAPTMEN1KMT2ATDP1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137889-A | Hypotensive agents; coronary vasodilators; calcium antagonists; antiinflammatory agents | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-08-11 | — | — | US | disclosed |
| US-5034395-A | Hypotensive agents, carboxylated dihydropyridines | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-07-23 | — | — | US | disclosed |
| US-4795814-A | CORONARY VASODILATORS, HYPOTENSIVE AGENTS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTTS, ENZYME INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-03 | — | — | US | disclosed |