Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | GALR3 | O60755 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10763910 | 0.87 | PDE3B (0.54) | PDE3BPDE3APBRM1PDE4APDE4B | |
| SCHEMBL10762928 | 0.86 | PDE3B (0.45) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10763316 | 0.85 | PDE3B (0.50) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10762769 | 0.81 | PDE3B (0.33) | PDE3BPDE3APBRM1BRD4CREBBP | |
| SCHEMBL10762017 | 0.81 | PDE3B (0.37) | PDE3BPDE3APBRM1BRD4CREBBP | |
| SCHEMBL10765731 | 0.81 | PDE3A (0.45) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10765212 | 0.81 | PDE3A (0.45) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10762088 | 0.79 | PDE3A (0.42) | PDE3BPDE3APTGS1PTGS2PBRM1 | |
| SCHEMBL10759912 | 0.79 | PTGS1 (0.57) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10763361 | 0.78 | PDE3B (0.46) | PDE3BPDE3APTGS1PTGS2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |