Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10765802 | 0.87 | PDE3B (0.55) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10763903 | 0.84 | PDE3B (0.47) | PDE3BPDE3APTGS1PTGS2PDE4A | |
| SCHEMBL10766164 | 0.83 | PDE3B (0.52) | PDE3BPDE3APTGS1PTGS2PDE4A | |
| SCHEMBL10769532 | 0.81 | PDE3B (0.37) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10765095 | 0.81 | PDE3B (0.33) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10759927 | 0.79 | PDE3B (0.48) | PDE3BPDE3APTGS1PTGS2MAOB | |
| SCHEMBL10762902 | 0.79 | PDE3A (0.43) | PDE3BPDE3APTGS1PTGS2PDE4B | |
| SCHEMBL10765577 | 0.78 | PDE3B (0.47) | PDE3BPDE3APTGS1PTGS2PDE4A | |
| SCHEMBL10760131 | 0.78 | PDE3B (0.45) | PDE3BPDE3APTGS1PTGS2PDE4A | |
| SCHEMBL10762761 | 0.78 | PTGS1 (0.58) | PDE3BPDE3APTGS1PTGS2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |