Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 15/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10761471 | 0.86 | KDM4E (0.59) | METAP1CYP2C9KDM4EL3MBTL1 | |
| SCHEMBL10757606 | 0.82 | KDM4E (0.56) | METAP1CYP2C9KDM4EL3MBTL1 | |
| SCHEMBL10761697 | 0.81 | ACP1 (0.43) | METAP1KDM4EL3MBTL1 | |
| SCHEMBL31310819 | 0.78 | METAP1 (0.97) | METAP1CYP2C9KDM4EL3MBTL1 | |
| SCHEMBL2551229 | 0.78 | METAP1 (0.97) | METAP1CYP2C9KDM4EL3MBTL1 | |
| SCHEMBL2547815 | 0.77 | METAP1 (1.00) | METAP1CYP2C9KDM4EL3MBTL1 | |
| SCHEMBL31310818 | 0.77 | METAP1 (1.00) | METAP1CYP2C9KDM4EL3MBTL1 | |
| SCHEMBL2545683 | 0.70 | METAP1 (1.00) | METAP1 | |
| SCHEMBL10757052 | 0.68 | KDM4E (0.50) | KDM4EL3MBTL1 | |
| SCHEMBL10760748 | 0.68 | CYP2C9 (1.00) | METAP1CYP2C9PKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4711890-A | TREATMENT OF ANXIETY STATES OR OF PULMONARY, RENAL, CIRCULATORY OF CARDIOVASCULAR DISORDERS | RHONE-POULENC SANTE (FR) | 1987-12-08 | — | — | US | disclosed |
| US-4684652-A | TREATING ANXIETY OR CARDIOVASCULAR DISORDERS | RHONE-POULENC SANTE (FR) | 1987-08-04 | — | — | US | disclosed |