Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | BAD | Q92934 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27780371 | 0.82 | PTPN1 (0.47) | PTPN1CES2CES1BCL2L1BAD | |
| SCHEMBL891617 | 0.82 | PTPN1 (0.47) | PTPN1CES2CES1BCL2L1BAD | |
| SCHEMBL8622826 | 0.77 | CES2 (0.52) | PTPN1CES2CES1BCL2L1BAD | |
| SCHEMBL2379291 | 0.73 | CES2 (0.48) | PTPN1CES2CES1BCL2L1BAD | |
| SCHEMBL28262930 | 0.73 | CES2 (0.48) | PTPN1CES2CES1BCL2L1BAD | |
| SCHEMBL31191256 | 0.72 | CES2 (0.64) | PTPN1CES2CES1BCL2L1BAD | |
| SCHEMBL18585299 | 0.72 | CES2 (0.56) | PTPN1CES2CES1BCL2L1BAD | |
| SCHEMBL835861 | 0.72 | CES2 (0.56) | PTPN1CES2CES1BCL2L1BAD | |
| SCHEMBL10580864 | 0.70 | CES2 (0.54) | PTPN1CES2CES1BCL2L1BAD | |
| SCHEMBL6726501 | 0.70 | CES2 (0.54) | PTPN1CES2CES1BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4704391-A | Pyridazinones, and pharmaceutical preparations thereof | CIBA-GEIGY CORPORATION (US) | 1987-11-03 | — | — | US | disclosed |
| US-4654340-A | Pyridazinones, pharmaceutical preparations containing these compounds, and the use thereof | CIBA-GEIGY CORPORATION (US) | 1987-03-31 | — | — | US | disclosed |
| US-4613599-A | Method of treating thrombotic disease with pyridazinones | CIBA-GEIGY CORPORATION (US) | 1986-09-23 | — | — | US | disclosed |